Clp Protease: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
-{{STRUCTURE_1tyf|  PDB=1tyf  | SIZE=350| SCENE= |right|CAPTION=E. coli Clp protease, [[1tyf]] }}
+<StructureSection load='1tyf' size='350' side='right' caption='E. coli Clp protease catalytic subunit (PDB entry [[1tyf]])' scene='50/508398/Cv/1'>
+== Function ==
+'''Clp protease''' (CLP) is a serine peptidase which hydrolyzes proteins in the presence of ATP and Mg+2 ion.  CLP is found in mitochondria.  CLP participates in degradation of misfolded proteins.<ref>PMID:2197275</ref><br />
-'''Clp protease''' (CLP) is a serine peptidase which hydrolyzes proteins in the presence of ATP and Mg+2 ion.  CLP is found in mitochondria.  CLP participates in degradation of misfolded proteins.  CLP is a heterodimer containing an ATP-binding regulatory subunit A and catalytic subunit P.  For more details see <br />
+For more details see <br />
 * [[Clp protease]]
-* [[Molecular Playground/ClpP]].
+* [[Zinc Fingers]]
+* [[Molecular Playground/ClpP]]
-==3D structures of Clp protease==
+* [[Molecular Playground/E. coli ClpP]].
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+'''Clp'''X or '''ATP-dependent Clp protease ATP-binding subunit ClpX''' is a molecular chaperone which alters the shape of DNA during bacteriophage μ transposition.<ref>PMID:21736903</ref>  For details see [[Molecular Playground/Hexameric ClpX]]
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*CLP P subunit
+== Structural highlights ==
-**[[1tyf]], [[1yg6]] – EcCLP – ''Escherichia coli''<br />
+CLP is a heterodimer containing an ATP-binding regulatory subunit A '''ClpA''' or Hsp100 in [[Heat Shock Proteins]] and catalytic subunit P '''ClpP'''.  The proteolytic complex is composed of <scene name='50/508398/Cv/2'>2 heptameric rings of ClpP</scene> flanked by hexameric rings of ClpA.  For full proteolytic activity ClpP must associate with one of two related ATPase subunits: '''ClpA''' and '''ClpX''' or '''ATP-binding Clp protease ATP-binding subunit ClpX'''.
-**[[1yg8]], [[3hln]] - EcCLP (mutant)<br />
-**[[1y7o]] – CLP – ''Streptococcus pneumoniae''<br />
-**[[1tg6]] - CLP – human<br />
-**[[2f6i]], [[4gm2]], [[4hnk]] - CLP – ''Plasmodium falciparum''<br />
-**[[2cby]], [[2ce3]], [[2c8t]], [[4u0h]] - MtCLP – ''Mycobacterium tuberculosis''<br />
-**[[3fes]] - CLP – ''Clostridium difficile''<br />
-**[[3ktg]], [[3kth]], [[3tt6]] – BsCLP – ''Bacillus subtilis''<br />
-**[[3p2l]] - CLP – ''Francisella tulerensis''<br />
-**[[3q7h]] - CLP – ''Coxiella burnetii''<br />
-**[[3qwd]], [[3st9]], [[3sta]], [[3v5e]], [[4emm]], [[4mxi]] - SaCLP – ''Staphylococcus aureus''<br />
-**[[3v5i]], [[4emp]] - SaCLP (mutant)<br />
-**[[2zl0]] - HpCLP – ''Helicobacter pylori''<br />
-**[[2zl3]] - HpCLP (mutant)<br />
-**[[4jcq]], [[4jct]], [[4ryf]] – LmCLP – ''Listeria monocytogenes''<br />
-**[[4jcr]] - LmCLP (mutant)<br />
-*''CLP P subunit complex''
+<scene name='45/458468/Cv/4'>ADP binding site</scene> in ''Helicobacter pylori'' ClpX (PDB entry [[1um8]]).<ref>PMID:14514695</ref>
-**[[2fzs]], [[3mt6]] - EcCLP + peptide<br />
+==3D structures of Clp protease==
-**[[2zl2]] - HpCLP + peptide<br />
+[[Clp protease 3D structures]]
-**[[2zl4]] - HpCLP (mutant) + peptide<br />
-**[[3kti]], [[3ktj]], [[3ktk]] - BsCLP + peptide<br />
-**[[3tt7]] - BsCLP + DFP<br />
-**[[4u0g]] – MtCLP + ADEP + agonist<br />
-*CLP A subunit
-**[[1k6k]], [[1r6c]] – EcCLP N terminal<br />
-**[[1ovx]] - EcCLP N terminal - NMR<br />
-**[[1ksf]], [[1r6b]] – EcCLP (mutant)<br />
-**[[1um8]] – HpCLP
-*''CLP A subunit binary complex''
-**[[1lzw]], [[1mg9]], [[1mbu]], [[1mbv]], [[1mbx]] – EcCLP + CLP adaptor protein ClpS<br />
+</StructureSection>
-**[[1r6o]], [[1r6q]] - EcCLP N terminal + CLP adaptor protein ClpS
-}}
+== References ==
+<references/>
 [[Category:Topic Page]]