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==Structure of a Yeast Centromeric Nucleosome at 2.7 Angstrom resolution==
==Structure of a Yeast Centromeric Nucleosome at 2.7 Angstrom resolution==
<StructureSection load='6uph' size='340' side='right'caption='[[6uph]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<SX load='6uph' size='340' side='right' viewer='molstar' caption='[[6uph]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6uph]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UPH FirstGlance]. <br>
<table><tr><td colspan='2'>[[6uph]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UPH FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSE4, CSL2, YKL049C, YKL262 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), KLLA0_E08647g, KLLA0_E17601g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica]), HTA1, KLLA0E17413g, HTA2, KLLA0F13332g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica]), HTB1, KLLA0F13310g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uph OCA], [https://pdbe.org/6uph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uph RCSB], [https://www.ebi.ac.uk/pdbsum/6uph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uph ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uph OCA], [http://pdbe.org/6uph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uph RCSB], [http://www.ebi.ac.uk/pdbsum/6uph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uph ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H2B1_KLULA H2B1_KLULA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/CENPA_YEAST CENPA_YEAST]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for functional chromatin architecture at the yeast 2-micron circle partitioning locus and promotes equal plasmid segregation.<ref>PMID:7698647</ref> <ref>PMID:9741625</ref> <ref>PMID:9584087</ref> <ref>PMID:10454560</ref> <ref>PMID:11063678</ref> <ref>PMID:10891506</ref> <ref>PMID:10499801</ref> <ref>PMID:11606525</ref> <ref>PMID:15590827</ref> <ref>PMID:16207811</ref> <ref>PMID:16966420</ref> [[http://www.uniprot.org/uniprot/Q6CMU6_KLULA Q6CMU6_KLULA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).[SAAS:SAAS00202799]
[https://www.uniprot.org/uniprot/CENPA_YEAST CENPA_YEAST] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for functional chromatin architecture at the yeast 2-micron circle partitioning locus and promotes equal plasmid segregation.<ref>PMID:7698647</ref> <ref>PMID:9741625</ref> <ref>PMID:9584087</ref> <ref>PMID:10454560</ref> <ref>PMID:11063678</ref> <ref>PMID:10891506</ref> <ref>PMID:10499801</ref> <ref>PMID:11606525</ref> <ref>PMID:15590827</ref> <ref>PMID:16207811</ref> <ref>PMID:16966420</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6uph" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6uph" style="background-color:#fffaf0;"></div>
==See Also==
*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Baker's yeast]]
[[Category: Kluyveromyces lactis NRRL Y-1140]]
[[Category: Candida sphaerica]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arthur, C P]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Ciferri, C]]
[[Category: Unidentified]]
[[Category: Dimitrova, Y N]]
[[Category: Arthur CP]]
[[Category: Harrison, S C]]
[[Category: Ciferri C]]
[[Category: Khin, Y]]
[[Category: Dimitrova YN]]
[[Category: Kschonsak, M]]
[[Category: Harrison SC]]
[[Category: Migl, D]]
[[Category: Khin Y]]
[[Category: Cell cycle]]
[[Category: Kschonsak M]]
[[Category: Centromere]]
[[Category: Migl D]]
[[Category: Histone]]
[[Category: Kinetochore]]
[[Category: Nucleosome]]
[[Category: Yeast]]

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