Proteopedia:Featured SEL/6: Difference between revisions

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<tr><td><div class='scrolling '>'''Coronavirus Spike Protein Membrane Fusion'''<br>
<tr><td><div class='scrolling '>'''Coronavirus Spike Protein Membrane Fusion'''<br>
''by Eric Martz''<br>
''by Eric Martz''<br>
SARS-CoV-2 spike protein undergoes a dramatic conformational rearrangement that plays a central role in fusing the coronavirus membrane with the host cell membrane. Similar conformational transformations have been observed for the spike protein of SARS-CoV and mouse hepatitis virus, among others. These rearrangements also have much in common with the membrane fusion mechansism of influenza hemagglutinin.
SARS-CoV-2 spike protein "spears" the host membrane with a <font color="#0060ff">'''fusion peptide'''</font> and drags the virus envelope membrane <font color="red">'''transmembrane domain'''</font> close to the host membrane, initiating fusion. This moves the virus RNA genome into the host cell, initiating infection.
>>> [[SARS-CoV-2_spike_protein_fusion_transformation|Visit this page]] >>>
<br>>>> [[SARS-CoV-2_spike_protein_fusion_transformation|Visit this page]] >>>
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Latest revision as of 00:07, 9 November 2022

Coronavirus Spike Protein Membrane Fusion

by Eric Martz
SARS-CoV-2 spike protein "spears" the host membrane with a fusion peptide and drags the virus envelope membrane transmembrane domain close to the host membrane, initiating fusion. This moves the virus RNA genome into the host cell, initiating infection.
>>> Visit this page >>>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky, Eric Martz
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