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default [[Immunodeficiency virus protease]]
default [[SARS-CoV-2 protein S priming by furin]]
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<tr><td><div class='scrolling '>'''SARS-CoV-2 protein S priming by furin'''<br>
<tr><td><div class='scrolling '>'''Coronavirus Spike Protein Priming'''<br>
''by Eric Martz''<br>
''by Eric Martz''<br>
Many copies of the spike protein of the coronavirus that causes COVID-19 are seen, in the electron microscope, sticking out from the surface of the virion (virus particle), making it look somewhat like a crown -- hence the name coronavirus. The spike protein is called protein S of the SARS-CoV-2 virus, and plays a central role in binding to host cells, and getting the RNA genes of the virus into the cell, initiating infection. Thus, knowledge of its protein molecular structure and function is crucial to developing effective therapies and vaccines.
Coronavirus SARS-CoV-2 (responsible for COVID-19) has a spike protein on its surface, which enables it to infect host cells. Initially, proteases in the lungs clip the homo-trimeric spike protein at a <font color="#e00000">'''unique sequence'''</font>. This primes it, causing it to extend its <font color="#e000e0">'''receptor binding surface'''</font> (shown in the above animation), optimizing binding to the host cell's ACE2 receptor (not shown). Next, spike protein initiates fusion of the virus and host cell membranes (not shown), enabling the virus RNA to enter the cell and initiate production of new virions. Knowledge of spike protein's molecular structure and function is crucial to developing effective therapies and vaccines.
 
<br>>>> [[SARS-CoV-2_protein_S_priming_by_furin|Visit this page]] >>>
>>> [[SARS-CoV-2_protein_S_priming_by_furin|Visit this page]] >>>
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