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Apoptotic protease-activating factor: Difference between revisions

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== Function ==
== Function ==


'''Apoptosis protease-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9.  Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.
'''Apoptosis protease-activating factor-1''' or '''Apoptosis peptidase-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9.  Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>.


== Disease ==
== Disease ==
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Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c<ref>PMID:26014357</ref>., caspase recruitment domain (CARD) and an ATPase domain.
*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; subunits H, I, J, K, L, M, N) and caspase 9 (magenta; subunits O, P, Q, R) (PDB entry [[5juy]]).  
*<scene name='77/774059/Cv/3'>Apoptosome</scene> formed by Human apoptosis protease-activating factor-1 (green; subunits A, B, C, D, E, F, G) complex with cytochrome c (red; subunits H, I, J, K, L, M, N) and caspase 9 (magenta; subunits O, P, Q, R) (PDB entry [[5juy]]).  
</StructureSection>


==3D structures of apoptotic protease-activating factor-1==
==3D structures of apoptotic protease-activating factor-1==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Apoptotic protease-activating factor-1 3D structures]]


[[2ygs]], [[1cy5]], [[2p1h]] – hAPAF-1 CARD domain – human  <br />
</StructureSection>
[[1c15]], [[1cww]] – hAPAF-1 CARD domain – NMR  <br />
[[1z6t]] – hAPAF-1 + ADP  <br />
[[3ygs]] – hAPAF-1 CARD domain + procaspase 9  <br />
[[4rhw]], [[5wvc]] – hAPAF-1 CARD domain + caspase 9  <br />
[[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br />
[[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br />
[[3sfz]] – mAPAF-1 + ADP - mouse  <br />
[[3shf]] – mAPAF-1 (mutant) + ADP  <br />


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel, Joel L. Sussman, Alexander Berchansky
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