4ec7: Difference between revisions
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==Cobra NGF in complex with lipid== | ==Cobra NGF in complex with lipid== | ||
<StructureSection load='4ec7' size='340' side='right' caption='[[4ec7]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='4ec7' size='340' side='right'caption='[[4ec7]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ec7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ec7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EC7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L44:(2S)-1-HYDROXY-3-(TETRADECANOYLOXY)PROPAN-2-YL+DOCOSANOATE'>L44</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L44:(2S)-1-HYDROXY-3-(TETRADECANOYLOXY)PROPAN-2-YL+DOCOSANOATE'>L44</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ec7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ec7 OCA], [https://pdbe.org/4ec7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ec7 RCSB], [https://www.ebi.ac.uk/pdbsum/4ec7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ec7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/NGFV_NAJAT NGFV_NAJAT]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4ec7" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Nerve growth factor|Nerve growth factor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
[[Category: Jiang | [[Category: Jiang T]] | ||
[[Category: Tong | [[Category: Tong Q]] | ||
[[Category: Wang | [[Category: Wang F]] | ||