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==Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist== | |||
<StructureSection load='7w6p' size='340' side='right'caption='[[7w6p]], [[Resolution|resolution]] 3.47Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7w6p]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W6P FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W96:N-pyridin-4-ylisoquinolin-4-amine'>W96</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w6p OCA], [https://pdbe.org/7w6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w6p RCSB], [https://www.ebi.ac.uk/pdbsum/7w6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w6p ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: Du | [[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: Shoichet | == Function == | ||
[[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Du Y]] | |||
[[Category: Fink EA]] | |||
[[Category: Shoichet BK]] | |||
[[Category: Xu J]] | |||
Latest revision as of 09:18, 28 September 2022
Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonistCryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist
Structural highlights
Disease[GNAO_HUMAN] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Function[GNAO_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. |
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