4dcp: Difference between revisions

<table><tr><td colspan='2'>[[4dcp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DCP FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dcp OCA], [https://pdbe.org/4dcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dcp RCSB], [https://www.ebi.ac.uk/pdbsum/4dcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dcp ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>  

*[[Caspase 3D structures|Caspase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Chung SJ]]

[[Category: Kang HJ]]

[[Category: Kim SJ]]