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| <StructureSection load='3gv2' size='400' side='right' caption='Structure of HIV-I coat protein hexamer (PDB entry [[3gv2]])' scene=''> | | <StructureSection load='' size='350' side='right' caption='Structure of HIV-I coat protein hexamer (PDB entry [[3gv2]])' scene='51/516486/Cv/1'> |
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| '''Virus coat proteins''' (VCP) or capsid proteins coat the virus. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. | | '''Virus coat proteins''' (VCP) or '''capsid proteins''' coat the virus<ref>PMID:14019094</ref>. The various VCPs are designated as Vp1, Vp2, etc. The VCP P domain (protruding domain) in noroviruses binds histo blood group antigen receptors. The outer capsid protein '''VP4''' is a virus spike-forming protein which mediates the virial attachment to the host epithelial cell receptors. The distal portion of Vp4 - '''Vp8*''' - is implicated in binding the cellular receptor<ref>PMID:22761376</ref>. VP4 is an outer capsid protein of non-enveloped viruses. VP4 attaches to sialic acid or to integrin heterodimers<ref>PMID:2538649</ref>. VP4 domains include: '''VP5*''' which forms the foot of the spike and acts in the permeabilization of the cell membrane and '''VP8*''' which forms the head of the spike and binds to sialic acid. |
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| ==3D structures of virus coat proteins==
| | The biological assembly of HIV-I coat protein is <scene name='51/516486/Cv/4'>homohexamer</scene> (PDB entry [[3gv2]]). |
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| ===VCP of parvovirus===
| | *Adeno-associated virus 9 Vp1 see [[Adeno-Associated Virus]]. |
| | *Ebola virus [[Journal:Acta Cryst F:S2053230X19004424|Structure of the Ebola virus nucleoprotein - RNA complex]] |
| | *Encephalitis virus, Eastern equine see [[FirstGlance/Virus Capsids and Other Large Assemblies#Eastern Equine Encephalitis Virus]] |
| | *[[Hiv-1 gag]] |
| | **[[Tumor susceptibility gene 101]] |
| | *[[Canine parvovirus|Parvovirus, canine]] |
| | *Poliovirus [[Journal:PLoS ONE:1|Antiviral Activity of 3(2H)- and 6-Chloro-3(2H)-Isoflavenes against Highly Diverged, Neurovirulent Vaccine-Derived, Type2 Poliovirus Sewage Isolates]] |
| | *Poliovirus capsid (interactive) at [[FirstGlance/Virus Capsids and Other Large Assemblies]] |
| | *[[Poliovirus receptor-related protein]] |
| | *[[Human rhinovirus|Rhinovirus, human]] |
| | *[[SV40 Capsid Simplified]] |
| | *[[Tobacco Mosaic Virus]] |
| | *[[User:Eric Martz/Virus capsid visualization resources|Virus capsid visualization resources]] |
| | *[[Hugo Heringer de Almeida/5YGH|Zika virus capsid protein]] |
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| [[2cas]] – cpvVCP - canine parvovirus<br />
| | ==3D structures of virus coat proteins== |
| [[1s58]] - VCP – human parvovirus<br />
| | [[Virus coat proteins 3D structures]] |
| [[1k3v]] – VCP Vp2 – pig parvovirus<br />
| | </StructureSection> |
| [[1ijs]], [[1p5w]], [[1p5y]] – cpvVCP (mutant) + DNA<br />
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| [[4dpv]] - cpvVCP + DNA
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| ===VCP of HIV=== | |
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| [[1afv]], [[1e6j]] – HivVCP + antibody – HIV-1<br />
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| [[3gv2]], [[3h47]], [[3h4e]] – HivVCP (mutant) <br />
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| [[1aum]], [[1a8o]], [[1a43]], [[2ont]], [[3lry]], [[3mge]] – HivVCP C terminal<br />
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| [[2jyl]], [[2jyg]] - HivVCP C terminal (mutant) – NMR<BR />
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| [[3dph]], [[3ds2]], [[3ds5]], [[3dtj]] - HivVCP C terminal (mutant) <br /> | |
| [[2buo]] - HivVCP C terminal + inhibitor of capsid assembly<br />
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| [[2xt1]], [[2xv6]], [[2xxm]] - HivVCP C terminal + camelid VHH 9<br />
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| [[3ds0]], [[3ds1]], [[3ds3]], [[3ds4]] - HivVCP C terminal (mutant) + inhibitor of capsid assembly<br />
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| [[1m9c]], [[1m9d]] - HivVCP N terminal + cyclophilin<br />
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| [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]] - HivVCP N terminal (mutant)+ cyclophilin<br />
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| [[2x82]], [[2x83]] – VCP N terminal – HIV-2
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| ===VCP of Rous sarcoma virus===
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| [[1d1d]] – RsvVCP – Rous sarcoma virus – NMR<BR />
| | == References == |
| [[1em9]], [[1p7n]] – RsvVCP N terminal<br />
| | <references/> |
| [[1eoq]], [[3g1g]], [[3g1i]], [[3g21]], [[2x8q]] - RsvVCP C terminal<br />
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| [[3g0v]], [[3g26]], [[3g28]], [[3g29]] - RsvVCP C terminal (mutant) <br />
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| [[3tir]] – RsvVCP P27
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| ===VCP of rotavirus===
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| [[1qhd]] – brvVCP Vp6 – bovine rotavirus<br />
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| [[3kz4]] - brvVCP Vp2<br />
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| [[2b4h]], [[2b4i]], [[2p3i]], [[2p3k]] - rrVCP Vp4 – rhesus rotavirus<br />
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| [[2p3j]] – rrVCP Vp4 (mutant) <br />
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| [[3gzt]], [[3gzu]] – rrVCP Vp7 – Cryo EM<BR />
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| [[2i2s]], [[3sis]], [[3sit]] - VCP Vp4 – pig rotavirus<br />
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| [[2dwr]] - hrvVCP Vp8* – human rotavirus<br />
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| [[4drr]], [[4drv]], [[4ds0]] - hrvVCP Vp8* + antigen
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| ===VCP of hepatitis virus===
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| [[1qgt]], [[2qij]] – hbvVCP – hepatitis B virus<br />
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| [[3kxs]] – hbvVCP (mutant) <br />
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| [[2ztn]], [[3ggq]], [[2zzq]], [[3rkc]] - hevVCP – hepatitis E virus<br />
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| [[3rkd]] – hevVCP + antibody<br />
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| [[3iyo]] – hevVCP – Cryo EM<BR />
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| ===VCP of norovirus===
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| [[1ihm]], [[3by1]], [[3by2]], [[3d26]], [[2zl5]], [[2zl6]], [[2zl7]] – NvVCP – Norwalk virus<br />
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| [[3onu]], [[3ony]], [[2obr]], [[2obs]], [[2obt]], [[3lq6]], [[3lqe]], [[3ry8]] – NvVCP P domain<br />
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| [[3pa1]], [[3pa2]], [[3q38]], [[3q39]], [[3q3a]], [[3q6q]], [[3q6r]], [[3asp]], [[3asq]], [[3asr]], [[3ass]], [[3ast]] - NvVCP P domain + antigen<br />
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| [[3m8l]] – VCP – feline calcivirus<br />
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| [[3v7a]] – NvVCP P domain + antibody<br />
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| ===VCP of plant viruses===
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| [[1js9]], [[1yc6]] – VCP – brome mosaic virus<br />
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| [[1f15]] – VCP – cucumber mosaic virus<br />
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| [[1auy]], [[1w39]] – VCP – turnip yellow mosaic virus<br />
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| [[3zxa]] - tcvVCP – turnip crinkle virus<br />
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| [[3zx8]], [[3zx9]] – tcvVCP – Cryo EM<BR />
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| [[1f2n]] - VCP – rice yellow mosaic virus<br />
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| [[1a34]], [[2tmv]], [[1ei7]] – tmvVCP + RNA]] - satellite tobacco mosaic virus<br />
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| [[3j06]] - tmvVCP + RNA – Cryo EM<BR />
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| [[2om3]], [[2xea]] – tmvVCP – Cryo EM<BR />
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| [[3kml ]]– tmvVCP (mutant) <br />
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| [[2buk]] - VCP]] - satellite tobacco necrosis virus<br />
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| [[1a6c]] - VCP]] - tobacco ringspot virus<br />
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| [[1e57]] – VCP – Physalis mottle virus<br />
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| [[2izw]] - VCP – ryegrass mottle virus<br />
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| [[1opo]] - VCP – carnation mottle virus<br />
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| [[1ny7]], [[1cwp]] – VCP – cowpea mosaic virus<br />
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| [[1za7]] - VCP (mutant) – cowpea chlorotic mottle virus<br />
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| [[1pgl]], [[1pgw]] – VCP + RNA – bean pod mottle virus<br />
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| [[2tbv ]]– VCP – tomato bushy stunt virus<br />
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| [[1smv]] – VCP – sesbania mosaic virus<br />
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| [[1stm]] – VCP - satellite panicum mosaic virus<br />
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| [[4sbv]] – VCP – southern bean mosaic virus<br />
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| [[1m1c]] – VCP – yeast L-A virus<br />
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| [[1laj]] – VCP + RNA – tomato aspermy virus<br />
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| [[1uf2]] – VCP + proteins – rice dwarf virus<br />
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| [[3iym]] – VCP – Penicillium stoloniferum virus – Cryo EM<BR />
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| ===VCP by fiber diffraction===
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| [[1cgm]] – VCP – cucumber green mottle virus<br />
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| [[1rmv]] - VCP + RNA – fibgrass mosaic virus<br />
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| [[1pfi]], [[2ifm]] – VCP – Pf1 virus<br />
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| [[1vtm]] - VCP - satellite tobacco mosaic virus<br />
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| ===VCP of various viruses ===
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| [[2mev]], [[1mec]] – VCP – mengo virus<br />
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| [[2snv]], [[2snw]], [[1svp]], [[1kxa]], [[1wyk]] – svVCP – sindbis virus<br />
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| [[1svp]], [[1kxb]], [[1kxc]], [[1kxd]], [[1kxe]], [[1kxf]] – svVCP (mutant)
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| [[1ld4]], [[3j0f]] – svVCP + envelope proteins – Cryo EM<BR />
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| [[1bvp]] – VCP – bluetongue virus VP7<br />
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| [[1nov]] – VCP – Nodamura virus<br />
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| [[1mvm]], [[1z1c]] – mvVCP + DNA – minute virus<br />
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| [[2xgk]] – mvVCP Vp2 (mutant) <br />
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| [[1bbt]], [[1fod]], [[1fmd]], [[1qgc]] – fmdvVCP – foot and mouth disease virus<br />
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| [[2wv4]], [[2wv5]] – fmdvVCP Vp1 + picornain<br />
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| [[1fpv]], [[1c8e]], [[1c8f]], [[1c8g]] – VCP – feline panleukopenia virus<br />
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| [[1c8d]], [[1c8h]] - VCP – canine panleukopenia virus<br />
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| [[2bbv]] – VCP + RNA – black beetle virus<br />
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| [[1pov]] – VCP – poliovirus<br />
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| [[1sva]] – svVCP – simian virus 40<br />
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| [[3bwq]], [[3bwr]] – svVCP Vp1
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| [[1sid]], [[1sie]], [[1vpn]], [[1vps]], [[1cn3]] – VCP – murine polyomavirus<br />
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| [[3s7v]] - pvVCP Vp1 – polyomavirus<br />
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| [[3s7x]] - pvVCP Vp1 (mutant) <br />
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| [[1vcp]], [[1vcq]] – VCP – semliki forest virus<br />
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| [[2yew]] - VCP + envelope glycoprotein – Barmah forest virus - Cryo EM<BR />
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| [[2eia]], [[1eia]] – VCP – equine infectious anemia virus<br />
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| [[1dnv]] – VCP – Galleria mellonella densovirus<br />
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| [[1ep5]], [[1ep6]] – eevVCP C terminal – equine encephalitis virus<br />
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| [[3j0c]] - eevVCP C terminal + envelope glycoprotein – Cryo EM<BR />
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| [[3ve6]] – eevVCP NLS + importin<br />
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| [[1qrj]] – HtlvVCP – HumanT-cell lymphotrophic virus – NMR<BR />
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| [[1g03]] - HtlvVCP N terminal]] - NMR<BR />
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| [[1dzl]] – hpvVCP L1 (mutant) – Human papillomavirus<br />
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| [[3iyj]] - VCP L1 – bovine papillomavirus – Cryo EM<BR />
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| [[2r5h]], [[2r5i]], [[2r5j]], [[2r5k]] - hpvVCP L1<br />
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| [[1f8v – VCP + RNA – pariacoto virus<br />
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| [[2r18]], [[2z7j – VCP Vp3 – birnavirus<br />
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| [[2vf1]] – VCP – rabbit picobirnavirus<br />
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| [[1jew]] – VCP + receptor – coxsackievvirus – Cryo EM<BR />
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| [[1fn9]] – VCP sigma 3 – reovirus<br />
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| [[3iyl]] – VCP Vp4+Vp1+Vp3 – grass carp virus – Cryo EM<BR />
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| [[1lp3]], [[2g8g]], [[2qa0]], [[3ra2]], [[3ra4]], [[3ra8]], [[3ra9]], [[3raa]], [[3ng9]] – aavVCP – adeno-associated virus<br />
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| [[3kic]], [[3kie]], [[1vu0]], [[1vu1]], [[3shm]], [[3tsx]], [[3ux1]] – aavVCP Vp1<br />
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| [[3j1s]] - aavVCP Vp1 + antibody<br />
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| [[2gh8]] – VCP – San Miguel sea lion virus<br />
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| [[1j5q]], [[1m3y]] – PbcvVCP – Parmecium bursaria chlorella virus<br />
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| [[1m4x]] – PbcvVCP – Cryo EM<BR />
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| [[1no7]] – VCP Vp5 – Human herpes simplex virus<br />
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| [[1ohf]] – VCP – Nudaurelia capensis omega virus<br />
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| [[1mqt]] – VCP – swine vesicular disease virus<br />
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| [[2p5p]] – VCP domain III – West Nile virus<br />
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| [[3cnf]] – VCP Vp1+Vp3 – polyhedrosis virus – Cryo EM<BR />
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| [[2v4x]] – VCP N terminal – sheep retrovirus<br />
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| [[3fbm]] – VCP Vp2 – avian infectious bursal disease virus<br />
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| [[2qqp]] – VCP + RNA – Providence virus<br />
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| [[2kgf ]]– mpmvVCP N-terminal – Mason-Pfizer monkey virus<br />
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| [[4ard]] – mpmvVCP P27 – Cryo EM<BR />
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| [[3ide]] – VCP Vp2 – infectious pancreatic necrosis virus<br />
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| [[3lob]], [[4fte]], [[4fts]] – fhvVCP (mutant) + RNA – flock house virus<br />
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| [[4fsj]], [[4ftb]] - fhvVCP + RNA<br />
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| [[3nap]] – VCP – triatoma virus<br />
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| [[2xgu]], [[2xgv]] – relvVCP N terminal – rabbit endogenous lentivirus<br />
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| [[3zue]] – VCP Vp60]] - rabbit hemorrhagic disease virus – Cryo EM<BR />
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| [[2xgy]] – relvVCP N terminal + cyclophilin<br />
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| [[3r0r]] – VCP – pig circovirus<br />
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| [[3izx]] – bmcvVCP Vp3 + structural protein 5 – Bombyx mori cypovirus<br /> – Cryo EM<BR />
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| [[3j17]] - bmcvVCP Vp3 Vp5<br />
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| [[3vbf]], [[3vbh]], [[3vbo]], [[3vbr]], [[3vbs]], [[3vbu]] – VCP – human enterovirus<br />
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| [[3s6p]] – VCP – Helicoverpa armigera stunt virus<br />
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| </StructureSection>
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |