4crt: Difference between revisions
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234== | ==Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234== | ||
<StructureSection load='4crt' size='340' side='right' caption='[[4crt]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4crt' size='340' side='right'caption='[[4crt]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4crt]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4crt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CRT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASS:(E)-N-METHYL-N-[[1-METHYL-5-[3-[1-(PHENYLMETHYL)PIPERIDIN-4-YL]PROPOXY]INDOL-2-YL]METHYL]PROP-1-EN-1-AMINE'>ASS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASS:(E)-N-METHYL-N-[[1-METHYL-5-[3-[1-(PHENYLMETHYL)PIPERIDIN-4-YL]PROPOXY]INDOL-2-YL]METHYL]PROP-1-EN-1-AMINE'>ASS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4crt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crt OCA], [https://pdbe.org/4crt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4crt RCSB], [https://www.ebi.ac.uk/pdbsum/4crt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4crt ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 17: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4crt" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Monoamine oxidase|Monoamine oxidase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Allan | [[Category: Allan J]] | ||
[[Category: Binda | [[Category: Binda C]] | ||
[[Category: Esteban | [[Category: Esteban G]] | ||
[[Category: Marco-Contelles | [[Category: Marco-Contelles J]] | ||
[[Category: Mattevi | [[Category: Mattevi A]] | ||
[[Category: Ramsay | [[Category: Ramsay RR]] | ||
[[Category: Samadi | [[Category: Samadi A]] | ||
[[Category: Unzeta | [[Category: Unzeta M]] | ||