7tzc: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 7tzc is ON HOLD
+==A drug and ATP binding site in type 1 ryanodine receptor==
+<StructureSection load='7tzc' size='340' side='right'caption='[[7tzc]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors: Melville, Z., Dridi, H., Yuan, Q., Reiken, S., Anetta, W., Clarke, O.B., Marks, A.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7tzc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZC FirstGlance]. <br>
-Description: A drug and ATP binding site in type 1 ryanodine receptor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CFF:CAFFEINE'>CFF</scene>, <scene name='pdbligand=KVR:4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic+acid'>KVR</scene>, <scene name='pdbligand=L9R:(2S)-3-(OCTADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>L9R</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tzc OCA], [https://pdbe.org/7tzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tzc RCSB], [https://www.ebi.ac.uk/pdbsum/7tzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tzc ProSAT]</span></td></tr>
-[[Category: Anetta, W]]
+</table>
-[[Category: Dridi, H]]
+== Disease ==
-[[Category: Melville, Z]]
+[[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.  The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
-[[Category: Marks, A.R]]
+== Function ==
-[[Category: Reiken, S]]
+[[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
-[[Category: Clarke, O.B]]
+== References ==
-[[Category: Yuan, Q]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Anetta W]]
+[[Category: Clarke OB]]
+[[Category: Dridi H]]
+[[Category: Liu Y]]
+[[Category: Marks AR]]
+[[Category: Melville Z]]
+[[Category: Reiken S]]
+[[Category: Yuan Q]]