4bu2: Difference between revisions
New page: '''Unreleased structure''' The entry 4bu2 is ON HOLD Authors: CHOWDHURY, R., CLIFTON, I.J., MCDONOUGH, M.A., NG, S.S., PILKA, E., OPPERMANN, U., SCHOFIELD, C.J. Description: An oxygena... |
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==60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG)== | |||
<StructureSection load='4bu2' size='340' side='right'caption='[[4bu2]], [[Resolution|resolution]] 2.78Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BU2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bu2 OCA], [https://pdbe.org/4bu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bu2 RCSB], [https://www.ebi.ac.uk/pdbsum/4bu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bu2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/RIOX2_HUMAN RIOX2_HUMAN]] Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.<ref>PMID:12091391</ref> <ref>PMID:14695334</ref> <ref>PMID:15534111</ref> <ref>PMID:15819408</ref> <ref>PMID:15897898</ref> <ref>PMID:17317935</ref> <ref>PMID:19502796</ref> <ref>PMID:23103944</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chowdhury R]] | |||
[[Category: Clifton IJ]] | |||
[[Category: McDonough MA]] | |||
[[Category: Ng SS]] | |||
[[Category: Oppermann U]] | |||
[[Category: Pilka E]] | |||
[[Category: Schofield CJ]] | |||