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| ==HLA-A11 complexed with a mutated peptide== | | ==Crystal Structure of HLA-A*1101 in complex with H7-22, an influenza A(H7N9) virus epitope== |
| <StructureSection load='4mj6' size='340' side='right' caption='[[4mj6]], [[Resolution|resolution]] 2.57Å' scene=''> | | <StructureSection load='4mj6' size='340' side='right'caption='[[4mj6]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[4mj6]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MJ6 FirstGlance]. <br> | | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MJ6 FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mj5|4mj5]]</td></tr> | | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mj6 OCA], [https://pdbe.org/4mj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mj6 RCSB], [https://www.ebi.ac.uk/pdbsum/4mj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mj6 ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mj6 OCA], [http://pdbe.org/4mj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mj6 RCSB], [http://www.ebi.ac.uk/pdbsum/4mj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mj6 ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Disease ==
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| [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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| == Function ==
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| [[http://www.uniprot.org/uniprot/1A11_HUMAN 1A11_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/R4X2K3_9INFA R4X2K3_9INFA]] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.[SAAS:SAAS00107710] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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| ==See Also== | | ==See Also== |
| *[[Beta-2 microglobulin|Beta-2 microglobulin]] | | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Gao, G F]] | | [[Category: Large Structures]] |
| [[Category: Liu, J]] | | [[Category: Gao GF]] |
| [[Category: Qi, J]] | | [[Category: Liu J]] |
| [[Category: Tan, S]] | | [[Category: Qi J]] |
| [[Category: Zhao, M]] | | [[Category: Tan S]] |
| [[Category: Immune system-peptide complex]]
| | [[Category: Zhao M]] |
| [[Category: Mhc]]
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| [[Category: T cell response]]
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