4b8t: Difference between revisions
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==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.== | ==RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.== | ||
<StructureSection load='4b8t' size='340' side='right' caption='[[4b8t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='4b8t' size='340' side='right'caption='[[4b8t]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4b8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8T FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8t OCA], [https://pdbe.org/4b8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8t RCSB], [https://www.ebi.ac.uk/pdbsum/4b8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN]] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4b8t" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Briata, P]] | [[Category: Briata, P]] | ||
[[Category: Garcia-Mayoral, M F]] | [[Category: Garcia-Mayoral, M F]] | ||