4b1q: Difference between revisions
New page: '''Unreleased structure''' The entry 4b1q is ON HOLD until sometime in the future Authors: Hocking, H.G., Gerwig, G.J., Favreau, P., Stocklin, R., Kamerling, J.P., Boelens, R. Descript... |
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==NMR structure of the glycosylated conotoxin CcTx from Conus consors== | |||
<StructureSection load='4b1q' size='340' side='right'caption='[[4b1q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1Q FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [https://pdbe.org/4b1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [https://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/CEX_CONCN CEX_CONCN]] May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The glycopeptide CcTx, isolated from the venom of the piscivorous cone snail Conus consors, belongs to the kappaA-family of conopeptides. These toxins elicit excitotoxic responses in the prey by acting on voltage-gated sodium channels. The structure of CcTx, a first in the kappaA-family, has been determined by high-resolution NMR spectroscopy together with the analysis of its O-glycan at Ser7. A new type of glycopeptide O-glycan core structure, here registered as core type 9, containing two terminal L-galactose units {alpha-L-Galp-(1-->4)-alpha-D-GlcpNAc-(1-->6)-[alpha-L-Galp-(1-->2)-beta-D-Galp-( 1-->3)-]alpha-D-GalpNAc-(1-->O)}, is highlighted. A sequence comparison to other putative members of the kappaA-family suggests that O-linked glycosylation might be more common than previously thought. This observation alone underlines the requirement for more careful and in-depth investigations into this type of post-translational modification in conotoxins. | |||
Structure of the O-Glycosylated Conopeptide CcTx from Conus consors Venom.,Hocking HG, Gerwig GJ, Dutertre S, Violette A, Favreau P, Stocklin R, Kamerling JP, Boelens R Chemistry. 2013 Jan 14;19(3):870-9. doi: 10.1002/chem.201202713. Epub 2012 Dec, 27. PMID:23281027<ref>PMID:23281027</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4b1q" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Conus consors]] | |||
[[Category: Large Structures]] | |||
[[Category: Boelens, R]] | |||
[[Category: Favreau, P]] | |||
[[Category: Gerwig, G J]] | |||
[[Category: Hocking, H G]] | |||
[[Category: Kamerling, J P]] | |||
[[Category: Stocklin, R]] | |||
[[Category: O-glycan]] | |||
[[Category: Toxin]] | |||