Stringent starvation protein: Difference between revisions
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<StructureSection load='5u51' size='340' side='right' caption='SspA ( | <StructureSection load='5u51' size='340' side='right' caption='SspA (deep sky blue) complex with MglA (pink), ppGpp, glycerol, PEG400 (PDB ID [[5u51]])' scene='91/917934/Cv/2'> | ||
== Function == | == Function == | ||
'''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. | '''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism, acid tolerance<ref>PMID:15819627</ref> and virulence of bacteria<ref>PMID:32785630</ref>. | ||
In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. | In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. '''Stringent starvation protein B''' (SspB) binds to residues in the tag of tmRNA proteins marking them for degradation <ref>PMID:11535833</ref>. | ||
== Relevance == | == Relevance == | ||
Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators. | Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators<ref>PMID:31648246</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:28864445</ref>. | The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:28864445</ref>. The <scene name='91/917934/Cv/5'>ppGpp molecule binds to the open face of the SspA-MglA heterodimer interacting with both molecules</scene>. | ||
== 3D structures of stringent starvation protein == | == 3D structures of stringent starvation protein == | ||
[[Stringent starvation protein 3D structures]] | [[Stringent starvation protein 3D structures]] | ||