Stringent starvation protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='6wmr' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='5u51' size='340' side='right' caption='SspA (deep sky blue) complex with MglA (pink), ppGpp, glycerol, PEG400 (PDB ID [[5u51]])' scene='91/917934/Cv/2'>
 == Function ==
-'''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>.
+'''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism, acid tolerance<ref>PMID:15819627</ref> and virulence of bacteria<ref>PMID:32785630</ref>.
+In ''Francisella'' virulence, a set of regulators are essensial for its activation.  These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR).  The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. '''Stringent starvation protein B''' (SspB) binds to residues in the tag of tmRNA proteins marking them for degradation <ref>PMID:11535833</ref>.
-== Disease ==
+== Relevance ==
-== Relevance ==
+Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators<ref>PMID:31648246</ref>.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:28864445</ref>. The <scene name='91/917934/Cv/5'>ppGpp molecule binds to the open face of the SspA-MglA heterodimer interacting with both molecules</scene>.
+== 3D structures of stringent starvation protein ==
+[[Stringent starvation protein 3D structures]]
 </StructureSection>
 == References ==
 <references/>
+[[Category:Topic Page]]