3ux9: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus== | ==Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus== | ||
<StructureSection load='3ux9' size='340' side='right' caption='[[3ux9]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='3ux9' size='340' side='right'caption='[[3ux9]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ux9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UX9 FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFNA1, IFNA13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ux9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ux9 OCA], [https://pdbe.org/3ux9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ux9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ux9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ux9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/IFNA1_HUMAN IFNA1_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<ref>PMID:1634550</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Line 20: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[3D structures | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Line 26: | Line 26: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Liang, M F]] | [[Category: Liang, M F]] | ||
[[Category: Liang, W]] | [[Category: Liang, W]] |