Syntenin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (deep sky blue and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene='91/916387/Cv/1'>
-<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''>
-This is a default text for your page '''Syntenin'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
-== Disease ==
+'''Syntenin''' (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes<ref>PMID:26032692</ref>
 == Relevance ==
+Exosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases.  SYNT is over-expressed in breast and gastric cancer
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. <scene name='91/916387/Cv/4'>Syntenin/Syndecan peptide inreactions</scene>. Water molecules are shown as red spheres.
+==Syntenin 3D structures==
+[[3D structures of syntenin]]
 </StructureSection>