Uridylate kinase: Difference between revisions

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Michal Harel, Alexander Berchansky

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-{{STRUCTURE_2j4k|  PDB=2j4k  | SIZE=400| SCENE= |right|   CAPTION=Uridylate kinase complex with ligand UMP, Cd+ and Mg+2 ions [[2j4k]] }}
+<StructureSection load='2j4k' size='350' side='right' caption='Uridylate kinase hexamer complex with ligand UMP, Cd+ (gold)  and Mg+2 (green) ions [[2j4k]]' scene='48/487531/Cv/1' >
+== Function ==
+'''Uridylate kinase''' (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source.  UDP is the starting point of synthesis of all other pyrimidine nucleotides.  The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP.  The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP.  The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain<ref>PMID:10218107</ref>.
-<!--
+== Structural highlights ==
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+The biological assembly of Uridylate kinase from ''Sulfolobus solfataricus'' ([[2j4k]]) is <scene name='48/487531/Cv/4'>homohexamer</scene>. The <scene name='48/487531/Cv/5'>active site of UK has high specificity to uracil</scene> and excludes purine nucleotides<ref>PMID:17297917</ref>. Water molecule is shown as red sphere.
-Or use the four-green-boxes-button to insert scrollable text adjacent
+</StructureSection>
-to a Jmol applet. Check out the other buttons as well!
+==3D structures of uridylate kinase==
--->
-'''Uridylate kinase''' (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source.  UDP is the starting point of synthesis of all other pyrimidine nucleotides.  The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP.  The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP.  The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain.
-==3D structures of uridylate kinase==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*Uridylate kinase
-[[1ybd]] – UK – ''Neisseria meningitides''<br />
+**[[1ybd]] – UK – ''Neisseria meningitides''<br />
-[[1z9d]] – UK – ''Streptococcus pyogenes''<br />
+**[[1z9d]] – UK – ''Streptococcus pyogenes''<br />
-[[2a1f]] - UK  - ''Haemophilus influenza''<br />
+**[[2a1f]] - UK  - ''Haemophilus influenza''<br />
-[[2brx]] – PfUK – ''Pyrococcus furiosus''<br />
+**[[2brx]] – PfUK – ''Pyrococcus furiosus''<br />
-[[2ij9]] – UK (mutant) – ''Archaeoglobus fulgidus''<br />
+**[[2ij9]] – UK (mutant) – ''Archaeoglobus fulgidus''<br />
-[[2va1]] - UK – ''Ureaplasma parvum''<br />
+**[[2va1]] - UK – ''Ureaplasma parvum''<br />
-[[3ek5]] – XcUK – ''Xanthomonas campestris''
+**[[3ek6]] – XcUK – ''Xanthomonas campestris''
-'''Uridylate kinase complex with nucleotides'''
+*Uridylate kinase complex with nucleotides
-[[1ukz]] – yUK + AMP + ADP<br />
+**[[1uky]] – yUK + ADP – yeast<br />
-[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br />
+**[[1ukz]] – yUK + AMP + ADP<br />
-[[2bnd]] - EcUK (mutant) + UDP<br />
+**[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br />
-[[2bnf]] - EcUK (mutant) + UTP<br />
+**[[2bnd]] - EcUK (mutant) + UDP<br />
-[[2v4y]] - EcUK (mutant) + GTP<br />
+**[[2bnf]] - EcUK (mutant) + UTP<br />
-[[2bmu]] - PfUK + UMP + AMPPNP<BR />
+**[[2v4y]] - EcUK (mutant) + GTP<br />
-[[2bri]] - PfUK + AMPPNP<BR />
+**[[2bmu]] - PfUK + UMP + AMPPNP<BR />
-[[2ji5]] - PfUK (mutant) + UTP<br />
+**[[2bri]] - PfUK + AMPPNP<BR />
-[[2j4j]] - SsUK + UMP + AMPPCP – Sulfolobus solfataricus<br />
+**[[2ji5]] - PfUK (mutant) + UTP<br />
-[[2j4k]] - SsUK + UMP<br />
+**[[2j4j]] - SsUK + UMP + AMPPCP – Sulfolobus solfataricus<br />
-[[2j4l]] - SsUK + UTP<br />
+**[[2j4k]] - SsUK + UMP<br />
-[[2jjx]] - UK + ATP + Mg – ''bacillus anthracis''<br />
+**[[2j4l]] - SsUK + UTP<br />
-[[1uky]] – yUK + ADP – yeast<br />
+**[[2jjx]] - UK + ATP + Mg – ''Bacillus anthracis''<br />
-[[3ek5]] - XcUK + GTP <br />
+**[[3ek5]] - XcUK + GTP <br />
-[[3nwy]] – UK + UTP + GTP – ''Mycobacterium tuberculosis''
+**[[3nwy]] – MtUK + UTP + GTP – ''Mycobacterium tuberculosis''<br />
+**[[7bex]], [[7bix]], [[7bl7]] - MtUK + UTP + UDP<br />
+**[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br />
+}}
+==References==
+<references />
+[[Category:Topic Page]]