Uridylate kinase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='2j4k' size='350' side='right' caption='Uridylate kinase hexamer complex with ligand UMP, Cd+ (gold)  and Mg+2 (green) ions [[2j4k]]' scene='48/487531/Cv/1' >
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+== Function ==
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+'''Uridylate kinase''' (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source.  UDP is the starting point of synthesis of all other pyrimidine nucleotides.  The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP.  The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP.  The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain<ref>PMID:10218107</ref>.
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--->
-'''Uridylate kinase''' (UK) catalyzes the reversible transfer of phosphate from UMP to UDP using ATP as a phosphate source.  UDP is the starting point of synthesis of all other pyrimidine nucleotides.  The eukaryotic UK has specificity to both UMP and CMP while the bacterial one is specific for UMP.  The bacterial UK is Mg+2 dependent and is activated by GTP and repressed by UTP.  The bacterial UK is composed of a C terminal ATP-binding domain and an N terminal UMP-binding domain.
+== Structural highlights ==
+The biological assembly of Uridylate kinase from ''Sulfolobus solfataricus'' ([[2j4k]]) is <scene name='48/487531/Cv/4'>homohexamer</scene>. The <scene name='48/487531/Cv/5'>active site of UK has high specificity to uracil</scene> and excludes purine nucleotides<ref>PMID:17297917</ref>. Water molecule is shown as red sphere.
+</StructureSection>
 ==3D structures of uridylate kinase==
-[[1ybd]] – UK – ''Neisseria meningitides''<br />
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1z9d]] – UK – ''Streptococcus pyogenes''<br />
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[2a1f]] - UK  - ''Haemophilus influenza''<br />
-[[2brx]] – PfUK – ''Pyrococcus furiosus''<br />
-[[2ij9]] – UK (mutant) – ''Archaeoglobus fulgidus''<br />
-[[2va1]] - UK – ''Ureaplasma parvum''<br />
-[[3ek5]] – XcUK – ''Xanthomonas campestris''
-'''Uridylate kinase complex with nucleotides'''
+*Uridylate kinase
-[[1ukz]] – yUK + AMP + ADP<br />
+**[[1ybd]] – UK – ''Neisseria meningitides''<br />
-[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br />
+**[[1z9d]] – UK – ''Streptococcus pyogenes''<br />
-[[2bnd]] - EcUK (mutant) + UDP<br />
+**[[2a1f]] - UK  - ''Haemophilus influenza''<br />
-[[2bnf]] - EcUK (mutant) + UTP<br />
+**[[2brx]] – PfUK – ''Pyrococcus furiosus''<br />
-[[2v4y]] - EcUK (mutant) + GTP<br />
+**[[2ij9]] – UK (mutant) – ''Archaeoglobus fulgidus''<br />
-[[2bmu]] - PfUK + UMP + AMPPNP<BR />
+**[[2va1]] - UK – ''Ureaplasma parvum''<br />
-[[2bri]] - PfUK + AMPPNP<BR />
+**[[3ek6]] – XcUK – ''Xanthomonas campestris''
-[[2ji5]] - PfUK (mutant) + UTP<br />
-[[2j4j]] - SsUK + UMP + AMPPCP – Sulfolobus solfataricus<br />
+*Uridylate kinase complex with nucleotides
-[[2j4k]] - SsUK + UMP<br />
-[[2j4l]] - SsUK + UTP<br />
+**[[1uky]] – yUK + ADP – yeast<br />
-[[2jjx]] - UK + ATP + Mg – ''bacillus anthracis''<br />
+**[[1ukz]] – yUK + AMP + ADP<br />
-[[1uky]] – yUK + ADP – yeast<br />
+**[[2bne]] – EcUK (mutant) + UMP – ''Escherichia coli''<br />
-[[3ek5]] - XcUK + GTP <br />
+**[[2bnd]] - EcUK (mutant) + UDP<br />
-[[3nwy]] – UK + UTP + GTP – ''Mycobacterium tuberculosis''
+**[[2bnf]] - EcUK (mutant) + UTP<br />
+**[[2v4y]] - EcUK (mutant) + GTP<br />
+**[[2bmu]] - PfUK + UMP + AMPPNP<BR />
+**[[2bri]] - PfUK + AMPPNP<BR />
+**[[2ji5]] - PfUK (mutant) + UTP<br />
+**[[2j4j]] - SsUK + UMP + AMPPCP – Sulfolobus solfataricus<br />
+**[[2j4k]] - SsUK + UMP<br />
+**[[2j4l]] - SsUK + UTP<br />
+**[[2jjx]] - UK + ATP + Mg – ''Bacillus anthracis''<br />
+**[[3ek5]] - XcUK + GTP <br />
+**[[3nwy]] – MtUK + UTP + GTP – ''Mycobacterium tuberculosis''<br />
+**[[7bex]], [[7bix]], [[7bl7]] - MtUK + UTP + UDP<br />
+**[[4a7x]], [[4a7w]] - UK + UDP – ''Helicobacter pylori''<br />
+}}
+==References==
+<references />
+[[Category:Topic Page]]