UMP/CMP kinase: Difference between revisions

Latest revision as of 11:11, 20 June 2022

Function

UMP/CMP kinase (UCK) or uridylmonophosphate/cytidylmonophosphate kinase phosphorylates UMP, CMP and deoxy-CMP^[1].

Relevance

Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK^[2].

Structure of human UMP/CMP kinase complex with sulfate (PDB entry 1tev)

Drag the structure with the mouse to rotate

3D Structures of UMP/CMP kinase3D Structures of UMP/CMP kinase

Updated on 20-June-2022

1tev, 7e9v – UCK – human
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor

ReferencesReferences

↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman

[1] Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191

[2] Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132

[1]

[2]

@@ Line 1: / Line 1: @@
-<StructureSection load='1tev' size='350' side='right' caption='Structure of human UMP/CMP kinase complex with sulfate (PDB entry [[1tev]])' scene=''>
+<StructureSection load='1tev' size='350' side='right' caption='Structure of human UMP/CMP kinase complex with sulfate (PDB entry [[1tev]])' scene='69/698098/Cv/1'>
-__TOC__
 == Function ==
@@ Line 7: / Line 7: @@
 == Relevance ==
-everal cytidine and deoxycytidine analogs are important anticancer and antiviral drugs.  These drugs require stepwise phosphorylation to exert their fully therapeutic effect.  This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
+Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs.  These drugs require stepwise phosphorylation to exert their fully therapeutic effect.  This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
 </StructureSection>
@@ Line 15: / Line 15: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[1tev]], [[7e9v]] – UCK – human <br />
 [[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br />
 [[4ukd]] – smUCK + ADP + UDP  <br />
 [[1uke]] – smUCK + inhibitor<br />
-[[1tev]] – UCK – human <br />
 == References ==
 <references/>
 [[Category:Topic Page]]