Tripeptidyl peptidase: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Glycosylated tripeptidyl peptidase I dimer complex with sulfate, Zn+2 (grey), Ca+2 (green) and Cl- (green) ions, [[3ee6]]' scene='43/433127/Cv/5'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
[[Tripeptidyl peptidase]] (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides.<br /> | [[Tripeptidyl peptidase]] or '''tripeptidyl aminopeptidase''' (TPP) is an enzyme which cleaves N-terminal tripeptides from polypeptides.<br /> | ||
* '''TPP-I''' functions in lysosomes.<br /> | * '''TPP-I''' functions in lysosomes<ref>PMID:29378960</ref>.<br /> | ||
* '''TPP-II''' is part of the ubiquitin-proteasome pathway. <br /> | * '''TPP-II''' is part of the ubiquitin-proteasome pathway. <br /> | ||
* '''TPP-IV''' is a serine exopeptidase which cleaves proline dipeptides from the N-terminus of polypeptides. | * '''TPP-IV''' is a serine exopeptidase which cleaves proline dipeptides from the N-terminus of polypeptides. | ||
== Didease == | == Didease == | ||
TPP-I participates in lysosomal turnover of proteins in pathological conditions associated with cell injury<ref>PMID:11589013</ref>. TPP-II deficiency is linked to severe autoimmunity<ref>PMID:25414442</ref>. TPP-II has central and peripheral roles in metabolism and hence in fat formation<ref>PMID:17932511</ref>. | TPP-I participates in lysosomal turnover of proteins in pathological conditions associated with cell injury and its mutations cause the fatal neurodegenerative childhood neuronal ceroid lipofuscinosis<ref>PMID:11589013</ref>. TPP-II deficiency is linked to severe autoimmunity<ref>PMID:25414442</ref>. TPP-II has central and peripheral roles in metabolism and hence in fat formation<ref>PMID:17932511</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
TPP-I catalytic triad is the | TPP-I catalytic triad is the typical <scene name='43/433127/Cv/6'>Ser-Glu-Asp</scene> and the active site contains an <scene name='43/433127/Cv/7'>octahedrally coordinated Ca+2 ion</scene><ref>PMID:19038966</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[2d5l]] - PgPro-TPP-IV<br /> | **[[2d5l]] - PgPro-TPP-IV<br /> | ||
**[[2z3w]] - PgPro-TPP-IV (mutant)<br /> | **[[2z3w]] - PgPro-TPP-IV (mutant)<br /> | ||
**[[2z3z]] | **[[2z3z]] - PgPro-TPP-IV (mutant)+inhibitor<br /> | ||
**[[2dcm]] - PgPro-TPP-IV (mutant) + substrate<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||