Interleukin: Difference between revisions
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* '''IL-4''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | * '''IL-4''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | ||
* '''IL-5''' stimulates B cell growth and increases immunoglobulin secretion.<br /> | * '''IL-5''' stimulates B cell growth and increases immunoglobulin secretion.<br /> | ||
* '''IL-6''' is both a pro-inflammatory cytokine and anti-inflammatory myokine. | * '''IL-6''' is both a pro-inflammatory cytokine and anti-inflammatory myokine. Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated [[Stepler sandbox STAT3|STAT3]] (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. Further investigation revealed that mutant [[EGFR]] could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. | ||
* '''IL-7''' is a cytokine important for B and T cells development.<br /> | * '''IL-7''' is a cytokine important for B and T cells development.<br /> | ||
* '''IL-8''' induces chemotaxis and phagocytosis.<br /> | * '''IL-8''' induces chemotaxis and phagocytosis.<br /> | ||
* '''IL-10''' see [[Interleukin-10]] and [[Inflammation & Rheumatoid Arthritis]].<br /> | * '''IL-10''' see [[Interleukin-10]] and [[Inflammation & Rheumatoid Arthritis]].<br /> | ||
* '''IL-11''' involved in the stimulation of megakaryocyte maturation.<br /> | * '''IL-11''' involved in the stimulation of megakaryocyte maturation.<br /> | ||
* ''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br /> | * ''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells. See [[Interleukin-12]].<br /> | ||
* '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | * '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | ||
* '''IL-15''' see [[Interleukin-15]].<br /> | * '''IL-15''' see [[Interleukin-15]].<br /> | ||