Sandbox 5: Difference between revisions

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<applet load='1axc' size='300' frame='true' align='right' caption='Insert caption here' />
==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='5eqh' size='350' side='right' caption='GLUT1 transporter in complex with inhibitor (PDB entry [[5eqh]])' scene=''>


　The crystal structure of the human DNA polymerase delta processivity factor <scene name='Sandbox_5/Pcna/5'>PCNA</scene>
Anything in this section will appear adjacent to the 3D structure and will be scrollable.
(proliferating cell nuclear antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution. p21 binds to PCNA in a 1:1 stoichiometry with an extensive array of interactions that include the formation of a beta sheet with the interdomain connector loop of PCNA. An intact trimeric ring is maintained in the structure of the p21-PCNA complex, with a central hole available for DNA interaction. The ability of p21 to inhibit the action of PCNA is therefore likely to be due to its masking of elements on PCNA that are required for the binding of other components of the polymerase assembly.


　Flap endonuclease-1 (FEN1) is a key enzyme for maintaining genomic stability and replication. <scene name='Sandbox_5/Fens-pcna/4'>FENS-PCNA</scene> interactions are similar to those previously observed for the p21CIP1/WAF1 peptide.
<scene name='10/101618/Glut1_n-glycosylation/1'>N-linked glycosylation</scene> site at Asn 45
 
</StructureSection>

Latest revision as of 21:44, 25 April 2022

Your Heading Here (maybe something like 'Structure')Your Heading Here (maybe something like 'Structure')


Anything in this section will appear adjacent to the 3D structure and will be scrollable.

site at Asn 45


GLUT1 transporter in complex with inhibitor (PDB entry 5eqh)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Student, Alexander Berchansky, Eran Hodis, Michael Skovbo Windahl, Mathilde Thomsen, Sara Toftegaard Petersen, Mette Trauelsen, Adam Kingsley
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