Tissue factor pathway inhibitor: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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 The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>.  TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207418</ref>.
 == Structural highlights ==
-In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/2'>hydrophobic residues of TFPI-2 interact with hydrophobic patch of trypsin</scene>.  An <scene name='70/707370/Cv/4'>Arg residue which is the P1 residue of TFPI-2 interacts with Asp - the S1 residue of trypsin</scene><ref>PMID:15932872</ref>. <scene name='70/707370/Cv/5'>Ca coordination site</scene>. Water molecules shown as red spheres.
+In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/6'>hydrophobic residues of TFPI-2 interact with hydrophobic patch</scene> of trypsin. An <scene name='70/707370/Cv/7'>Arg residue which is the P1 residue of TFPI-2 interacts with Asp - the S1 residue</scene> of trypsin<ref>PMID:15932872</ref>. <scene name='70/707370/Cv/8'>Ca coordination site</scene>. Water molecules are shown as red spheres.
 </StructureSection>
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 [[1irh]] – hTFPI-1 kunitz domain III - NMR<br />
 [[1tfx]] – hTFPI-1 kunitz domain II + trypsin <br />
+[[6bx8]] – hTFPI-1 kunitz domain I (mutant) + trypsin <br />
 [[1zr0]] – hTFPI-2 kunitz domain I + trypsin <br />
 [[5nmv]] – hTFPI-1 kunitz domain I + antibody <br />
 [[4dtg]] – hTFPI-1 kunitz domain II + antibody <br />
 [[4bqd]] – hTFPI-1 kunitz domain I + peptide <br />
+[[7v1n]] – hTFPI-1 + toxin B <br />
 == References ==
 <references/>
 [[Category:Topic Page]]