Tissue factor pathway inhibitor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II (grey and green) complex with trypsin (pink and yellow) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''>
+<StructureSection load='' size='350' side='right' caption='Human tissue factor pathway inhibitor 2 Kunitz domain I (green) complex with trypsin (cyan) and Ca+2 ion (PDB code [[1zr0]])' scene='70/707370/Cv/1'>
-'''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa.  TFPI contains three  Kunitz domains.  The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix.  Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa.
 == Function ==
+'''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa<ref>PMID:9112630</ref>.  TFPI contains three  Kunitz domains.  The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix.  Kunitz I and II domains inhibit VIIa coagulation factor while Kunitz II domain inhibits Xa.  Kunitz III domains probably involved in the interactions with lipoproteins.
-== Disease ==
 == Relevance ==
+The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>.  TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207418</ref>.
 == Structural highlights ==
+In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/6'>hydrophobic residues of TFPI-2 interact with hydrophobic patch</scene> of trypsin. An <scene name='70/707370/Cv/7'>Arg residue which is the P1 residue of TFPI-2 interacts with Asp - the S1 residue</scene> of trypsin<ref>PMID:15932872</ref>. <scene name='70/707370/Cv/8'>Ca coordination site</scene>. Water molecules are shown as red spheres.
 </StructureSection>
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+Tissue factor pathway inhibitor domains: kunitz I 29-118; kunitz II 121-178; kunitz III 210-270
 [[1adz]] – hTFPI-1 kunitz domain II (mutant) – human - NMR<br />
 [[1irh]] – hTFPI-1 kunitz domain III - NMR<br />
 [[1tfx]] – hTFPI-1 kunitz domain II + trypsin <br />
+[[6bx8]] – hTFPI-1 kunitz domain I (mutant) + trypsin <br />
 [[1zr0]] – hTFPI-2 kunitz domain I + trypsin <br />
+[[5nmv]] – hTFPI-1 kunitz domain I + antibody <br />
 [[4dtg]] – hTFPI-1 kunitz domain II + antibody <br />
 [[4bqd]] – hTFPI-1 kunitz domain I + peptide <br />
+[[7v1n]] – hTFPI-1 + toxin B <br />
 == References ==
 <references/>
+[[Category:Topic Page]]