Tau protein: Difference between revisions
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<StructureSection load='2MZ7' size='350' side='right' scene='' caption='Human tau protein (PBD codes: [[2mz7]], [[4np8]])'> | <StructureSection load='2MZ7' size='350' side='right' scene='' caption='Human tau protein (PBD codes: [[2mz7]], [[4np8]])'> | ||
==Structure and Function == | ==Structure and Function == | ||
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The human '''tau protein''', encoded by chromosome 17q21, has a natively unfolded protein structure, which contributes to its flexibility and ability to stabilize functional microtubules <ref name="mandelkow">PMID: 22762014</ref>. Specifically, its primary structure, consisting of <scene name='71/716561/Primary_tau/1'>serines, threonines, aspartates, glutamates, lysines, arginines, prolines, and aromatics</scene>, is highly hydrophilic compared to other cytosolic proteins <ref name="mandelkow"/>. It has a predominantly acidic N-terminal region, a proline-rich middle region, and a relatively neutral C-terminal region <ref name="mandelkow"/>. | The human '''tau protein''', encoded by chromosome 17q21, has a natively unfolded protein structure, which contributes to its flexibility and ability to stabilize functional microtubules <ref name="mandelkow">PMID: 22762014</ref>. Specifically, its primary structure, consisting of <scene name='71/716561/Primary_tau/1'>serines, threonines, aspartates, glutamates, lysines, arginines, prolines, and aromatics</scene>, is highly hydrophilic compared to other cytosolic proteins <ref name="mandelkow"/>. It has a predominantly acidic N-terminal region, a proline-rich middle region, and a relatively neutral C-terminal region <ref name="mandelkow"/>. | ||