Stimulator of interferon genes: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 == Structural highlights ==
-The 3D structure of the complex between human STING and cyclic GMP-AMP shows the dinucleotide bound by the symmetric dimer of STING. The <scene name='57/573101/Cv/5'>U-shaped cleft</scene> between the 2 subunits makes numerous interactions with the U-shaped ligand. <scene name='57/573101/Cv/4'>GMP-AMP binding site</scene> (water molecules are shown as red spheres). A <scene name='57/573101/Cv/6'>Tyr residue from each monomer stacks</scene> against each of the purine moieties while an Arg residue from each monomer forms hydrogen bonds to the dinucleotide <ref>PMID:23910378</ref>.
+The 3D structure of the complex between human STING and cyclic GMP-AMP shows the dinucleotide bound by the symmetric dimer of STING. The <scene name='57/573101/Cv/5'>U-shaped cleft</scene> between the 2 subunits makes numerous interactions with the U-shaped ligand. <scene name='57/573101/Cv/4'>GMP-AMP binding site</scene> (water molecules are shown as red spheres). A <scene name='57/573101/Cv/6'>Tyr residue from each monomer stacks</scene> against each of the purine moieties while an <scene name='57/573101/Cv/7'>Arg residue from each monomer forms hydrogen bonds to the dinucleotide</scene> <ref>PMID:23910378</ref>.
+==3D structures of stimulator of interferon genes protein==
+[[Stimulator of interferon genes protein 3D structures]]
 </StructureSection>
-==3D structures of stimulator of interferon genes protein==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Stimulator of interferon genes protein; domains - C-di-GMP-binding 154-341; PLPLRT/SD motif 342-379
-**[[6nt5]] – hSTING - human - Cryo EM<br />
-**[[4ef5]], [[4f5w]], [[4f9e]] – hSTING C-di-GMP-binding domain<br />
-**[[4f5e]], [[6mx0]] – hSTING C-di-GMP-binding domain (mutant)<br />
-**[[6iyf]] – pSTING C-di-GMP-binding domain - pig<br />
-**[[4kc0]] – mSTING C-di-GMP-binding domain - mouse<br />
-**[[5gs5]] – rSTING C-di-GMP-binding domain - rat<br />
-**[[6nt6]] – cSTING - chicken - Cryo EM<br />
-**[[5cfo]], [[5cfr]] – aSTING – anemone<br />
-*Stimulator of interferon genes protein complex
-**[[4ef4]], [[4emt]], [[4emu]], [[4f5y]], [[4f9g]], [[6rm0]], [[6s86]] – hSTING C-di-GMP-binding domain + GMP derivative<br />
-**[[4f5d]] – hSTING C-di-GMP-binding domain (mutant) + GMP derivative <br />
-**[[6cff]], [[6cy7]] – hSTING C-di-GMP-binding domain + AMP derivative <br />
-**[[4ksy]], [[4loh]], [[5bqx]], [[6dnk]], [[6xnp]], [[6s26]], [[6s27]] – hSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
-**[[4loi]], [[6mx3]], [[6mxe]] – hSTING C-di-GMP-binding domain (mutant) + GMP-AMP derivative <br />
-**[[6dxg]], [[6dxl]], [[6ukm]], [[6uku]], [[6ukv]], [[6ukw]], [[6ukx]], [[6uky]], [[6ukz]], [[6ul0]] – hSTING C-di-GMP-binding domain + agonist <br />
-**[[4qxo]] – hSTING C-di-GMP-binding domain + drug <br />
-**[[4qxp]], [[4qxq]], [[4qxr]] – hSTING C-di-GMP-binding domain (mutant) + drug <br />
-**[[5jej]] – hSTING PLPLRT/SD motif + IRF-3 CTD <br />
-**[[6o8b]], [[6o8c]] – hSTING PLPLRT/SD motif (mutant) + TBK1 <br />
-**[[6a03]], [[6a04]], [[6a05]], [[6a06]] – pSTING C-di-GMP-binding domain + ligand <br />
-**[[4kby]] – mSTING C-di-GMP-binding domain+ GMP derivative<br />
-**[[4loj]], [[4lok]], [[4yp1]] – mSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
-**[[6xnn]] – mSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
-**[[4lol]] – mSTING C-di-GMP-binding domain + drug <br />
-**[[4jc5]] – mSTING C-di-GMP-binding domain + immune activator <br />
-**[[5grm]] – rSTING C-di-GMP-binding domain + GMP-AMP derivative <br />
-**[[6nt7]], [[6nt8]] – cSTING + GMP-AMP derivative - Cryo EM<br />
-**[[6nt9]] – cSTING + TBK1 - Cryo EM<br />
-**[[5cfl]], [[5cfm]], [[5cfq]] – aSTING C-di-GMP-binding domain + GMP derivative <br />
-**[[5cfp]] – aSTING C-di-GMP-binding domain (mutant) + GMP derivative<br />
-**[[5cfn]] – aSTING C-di-GMP-binding domain + AMP derivative <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]