2v4x: Difference between revisions

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-{{Seed}}
-[[Image:2v4x.png|left|200px]]
-<!--
+==Crystal Structure of Jaagsiekte Sheep Retrovirus Capsid N-terminal domain==
-The line below this paragraph, containing "STRUCTURE_2v4x", creates the "Structure Box" on the page.
+<StructureSection load='2v4x' size='340' side='right'caption='[[2v4x]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2v4x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Endogenous_jaagziekte_retrovirus Endogenous jaagziekte retrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4X FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4x OCA], [https://pdbe.org/2v4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4x RCSB], [https://www.ebi.ac.uk/pdbsum/2v4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4x ProSAT]</span></td></tr>
-{{STRUCTURE_2v4x|  PDB=2v4x  |  SCENE=  }}
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4x_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4x ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Jaagsiekte sheep retrovirus is a betaretrovirus and the causative agent of pulmonary adenocarcinoma, a transmissible lung tumour of sheep. Here we report the crystal structure of the capsid amino-terminal domain and examine the self-association properties of Jaagsiekte sheep retrovirus capsid. We find that the structure is remarkably similar to the amino-terminal domain of the alpharetrovirus, avian leukosis virus, revealing a previously undetected evolutionary similarity. Examination of capsid self-association suggests a mode of assembly not driven by the strong capsid carboxy-terminal domain interactions that characterise capsid assembly in the lentiviruses. Based on these data, we propose this structure provides a model for the capsid of betaretroviruses including the HML-2 family of endogenous human betaretroviruses.
-===CRYSTAL STRUCTURE OF JAAGSIEKTE SHEEP RETROVIRUS CAPSID N-TERMINAL DOMAIN===
+Structure of the Capsid Amino-Terminal Domain from the Betaretrovirus, Jaagsiekte Sheep Retrovirus.,Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA J Mol Biol. 2008 Nov 5. PMID:19007792<ref>PMID:19007792</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2v4x" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19007792}}, adds the Publication Abstract to the page
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19007792 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_19007792}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Endogenous jaagziekte retrovirus]]
-V4X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Jaagsiekte_sheep_retrovirus Jaagsiekte sheep retrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4X OCA].
+[[Category: Large Structures]]
+[[Category: Goldstone, D C]]
-==Reference==
+[[Category: Haire, L F]]
-Structure of the Capsid Amino-Terminal Domain from the Betaretrovirus, Jaagsiekte Sheep Retrovirus., Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA, J Mol Biol. 2008 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19007792 19007792]
+[[Category: Mortuza, G B]]
-[[Category: Jaagsiekte sheep retrovirus]]
+[[Category: Palmarini, M]]
-[[Category: Single protein]]
+[[Category: Pashley, C]]
-[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
+[[Category: Stoye, J P]]
+[[Category: Taylor, I A]]
+[[Category: Taylor, W R]]
 [[Category: Capsid]]
 [[Category: Capsid protein]]
@@ Line 36: / Line 52: @@
 [[Category: Viral protein]]
 [[Category: Virion]]
-[[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  4 20:03:16 2009''