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==Crystal Structure of Jaagsiekte Sheep Retrovirus Capsid N-terminal domain== | |||
<StructureSection load='2v4x' size='340' side='right'caption='[[2v4x]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2v4x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Endogenous_jaagziekte_retrovirus Endogenous jaagziekte retrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4X FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4x OCA], [https://pdbe.org/2v4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4x RCSB], [https://www.ebi.ac.uk/pdbsum/2v4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4x ProSAT]</span></td></tr> | |||
</table> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4x_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4x ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Jaagsiekte sheep retrovirus is a betaretrovirus and the causative agent of pulmonary adenocarcinoma, a transmissible lung tumour of sheep. Here we report the crystal structure of the capsid amino-terminal domain and examine the self-association properties of Jaagsiekte sheep retrovirus capsid. We find that the structure is remarkably similar to the amino-terminal domain of the alpharetrovirus, avian leukosis virus, revealing a previously undetected evolutionary similarity. Examination of capsid self-association suggests a mode of assembly not driven by the strong capsid carboxy-terminal domain interactions that characterise capsid assembly in the lentiviruses. Based on these data, we propose this structure provides a model for the capsid of betaretroviruses including the HML-2 family of endogenous human betaretroviruses. | |||
Structure of the Capsid Amino-Terminal Domain from the Betaretrovirus, Jaagsiekte Sheep Retrovirus.,Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA J Mol Biol. 2008 Nov 5. PMID:19007792<ref>PMID:19007792</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2v4x" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Virus coat | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Goldstone, D C | [[Category: Endogenous jaagziekte retrovirus]] | ||
[[Category: Haire, L F | [[Category: Large Structures]] | ||
[[Category: Mortuza, G B | [[Category: Goldstone, D C]] | ||
[[Category: Palmarini, M | [[Category: Haire, L F]] | ||
[[Category: Pashley, C | [[Category: Mortuza, G B]] | ||
[[Category: Stoye, J P | [[Category: Palmarini, M]] | ||
[[Category: Taylor, I A | [[Category: Pashley, C]] | ||
[[Category: Taylor, W R | [[Category: Stoye, J P]] | ||
[[Category: Taylor, I A]] | |||
[[Category: Taylor, W R]] | |||
[[Category: Capsid]] | [[Category: Capsid]] | ||
[[Category: Capsid protein]] | [[Category: Capsid protein]] | ||
Latest revision as of 15:38, 23 March 2022
Crystal Structure of Jaagsiekte Sheep Retrovirus Capsid N-terminal domainCrystal Structure of Jaagsiekte Sheep Retrovirus Capsid N-terminal domain
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedJaagsiekte sheep retrovirus is a betaretrovirus and the causative agent of pulmonary adenocarcinoma, a transmissible lung tumour of sheep. Here we report the crystal structure of the capsid amino-terminal domain and examine the self-association properties of Jaagsiekte sheep retrovirus capsid. We find that the structure is remarkably similar to the amino-terminal domain of the alpharetrovirus, avian leukosis virus, revealing a previously undetected evolutionary similarity. Examination of capsid self-association suggests a mode of assembly not driven by the strong capsid carboxy-terminal domain interactions that characterise capsid assembly in the lentiviruses. Based on these data, we propose this structure provides a model for the capsid of betaretroviruses including the HML-2 family of endogenous human betaretroviruses. Structure of the Capsid Amino-Terminal Domain from the Betaretrovirus, Jaagsiekte Sheep Retrovirus.,Mortuza GB, Goldstone DC, Pashley C, Haire LF, Palmarini M, Taylor WR, Stoye JP, Taylor IA J Mol Biol. 2008 Nov 5. PMID:19007792[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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