Siderocalin: Difference between revisions

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<StructureSection load='' size='450' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' >
<StructureSection load='' size='350' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' >
__TOC__
== Function ==
== Function ==
'''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus  impeding their virulence<ref>PMID:19053425</ref>.
'''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus  impeding their virulence<ref>PMID:19053425</ref>.
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== Structural highlights ==
== Structural highlights ==
Scn-NGAL interacts with the <scene name='48/488406/Cv/3'>siderophore carboxymycobactin where the latter is centered in the protein calyx</scene> making <scene name='48/488406/Cv/2'>multiple interactions including cation-π bonds involving several lysines and arginine</scene><ref>PMID:15642259</ref>.
Scn-NGAL interacts with the <scene name='48/488406/Cv/4'>siderophore carboxymycobactin where the latter is centered in the protein calyx</scene> making <scene name='48/488406/Cv/5'>multiple interactions including cation-π bonds involving several lysines and arginine</scene><ref>PMID:15642259</ref>. Water  molecules are shown as red spheres. <scene name='48/488406/Cv/6'>Fe coordination site</scene>.


</StructureSection>
==3D structures of siderocalin==
==3D structures of siderocalin==
[[Siderocalin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Siderocalin or lipocalin-2
**[[5jr8]], [[3bx8]], [[5khp]], [[5kid]], [[5kic]] – hScn NGAL - human<br />
**[[3s26]] – mScn NGAL - mouse<br />
**[[2kt4]] – qScn Q83 – quail<br />
*Siderocalin complex
**[[4mvi]], [[4mvk]], [[4mvl]] – hScn NGAL (mutant) + β-amyloid protein 40 peptide<br />
**[[3bx7]] – hScn NGAL + CTLA-4<br />
**[[3tzs]] – hScn NGAL (mutant) + phenylurea<br />
**[[4zfx]], [[4zhc]], [[4zhd]], [[4zhf]], [[4zhg]], [[4zhh]], [[4qae]], [[4k19]], [[4aiw]], [[4aix]], [[3u03]], [[3u0d]], [[3k3l]], [[3dsz]], [[1x89]], [[1x8u]], [[1x71]] – hScn NGAL + siderophore<br />
**[[3tf6]], [[3t1d]], [[3i0a]], [[3hwd]] – hScn NGAL (mutant) + siderophore<br />
**[[3pec]], [[3ped]] – hScn NGAL + siderophore + Fe<br />
**[[3hwe]], [[3hwf]], [[3hwg]], [[3cmp]], [[3by0]], [[3cbc]] – hScn NGAL (mutant) + siderophore + Fe<br />
**[[3fw4]], [[3fw5]] – hScn NGAL (mutant) + catechol + Fe<br />
**[[4gh7]] – hScn NGAL + fibronectin<br />
**[[3u9p]] – mScn NGAL  + Fab <br />
**[[2lbv]] – qScn Q83 + enterobactin – NMR<br />
**[[3sao]] – cScn + myristoyl lysophosphatidic acid - chicken<br />
>
}}
==References==
==References==
</StructureSection>
<references />
<references />


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 11:20, 21 March 2022

Function

Siderocalin (Scn) or neutrophil gelatinase-associated lipocalin binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence[1].

Relevance

Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death[2].

Structural highlights

Scn-NGAL interacts with the making [3]. Water molecules are shown as red spheres. .

3D structures of siderocalin

Siderocalin 3D structures

References

Human siderocalin complex with the siderophore carboxymycobactin (PDB code 1x89)

Drag the structure with the mouse to rotate
  1. ↑ Hoette TM, Abergel RJ, Xu J, Strong RK, Raymond KN. The role of electrostatics in siderophore recognition by the immunoprotein Siderocalin. J Am Chem Soc. 2008 Dec 24;130(51):17584-92. doi: 10.1021/ja8074665. PMID:19053425 doi:http://dx.doi.org/10.1021/ja8074665
  2. ↑ Paragas N, Qiu A, Hollmen M, Nickolas TL, Devarajan P, Barasch J. NGAL-Siderocalin in kidney disease. Biochim Biophys Acta. 2012 Sep;1823(9):1451-8. doi: 10.1016/j.bbamcr.2012.06.014., Epub 2012 Jun 19. PMID:22728330 doi:http://dx.doi.org/10.1016/j.bbamcr.2012.06.014
  3. ↑ Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK. Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure. 2005 Jan;13(1):29-41. PMID:15642259 doi:10.1016/j.str.2004.10.009

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