Siderocalin: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' > | |||
__TOC__ | |||
== Function == | |||
'''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | |||
== Relevance == | |||
Scn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death<ref>PMID:22728330</ref>. | |||
== Structural highlights == | |||
Scn-NGAL interacts with the <scene name='48/488406/Cv/4'>siderophore carboxymycobactin where the latter is centered in the protein calyx</scene> making <scene name='48/488406/Cv/5'>multiple interactions including cation-π bonds involving several lysines and arginine</scene><ref>PMID:15642259</ref>. Water molecules are shown as red spheres. <scene name='48/488406/Cv/6'>Fe coordination site</scene>. | |||
==3D structures of siderocalin== | |||
[[Siderocalin 3D structures]] | |||
==References== | |||
</StructureSection> | |||
<references /> | |||
[[Category:Topic Page]] | |||
Latest revision as of 11:20, 21 March 2022
FunctionSiderocalin (Scn) or neutrophil gelatinase-associated lipocalin binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence[1]. RelevanceScn-NGAL levels are markedly upregulated by tissue damage. Scn-NGAL is derived from damaged kidneys. The presence of Scn-NGAL in serum or urine anticipates a severe course for the patient including the need for dialysis and the possibility of death[2]. Structural highlightsScn-NGAL interacts with the making [3]. Water molecules are shown as red spheres. . 3D structures of siderocalinReferences |
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- ↑ Hoette TM, Abergel RJ, Xu J, Strong RK, Raymond KN. The role of electrostatics in siderophore recognition by the immunoprotein Siderocalin. J Am Chem Soc. 2008 Dec 24;130(51):17584-92. doi: 10.1021/ja8074665. PMID:19053425 doi:http://dx.doi.org/10.1021/ja8074665
- ↑ Paragas N, Qiu A, Hollmen M, Nickolas TL, Devarajan P, Barasch J. NGAL-Siderocalin in kidney disease. Biochim Biophys Acta. 2012 Sep;1823(9):1451-8. doi: 10.1016/j.bbamcr.2012.06.014., Epub 2012 Jun 19. PMID:22728330 doi:http://dx.doi.org/10.1016/j.bbamcr.2012.06.014
- ↑ Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK. Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure. 2005 Jan;13(1):29-41. PMID:15642259 doi:10.1016/j.str.2004.10.009