SAICAR synthetase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='4fe2' size='450' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene='74/749400/Cv/1'>
+<StructureSection load='' size='350' side='right' caption='SAICAR synthetase complex with aminoimidazole-ribonucleotide, ADP, TRIS, aspartate, acetate, Mg+2 and Cl- ions (PDB code [[4fe2]]) ' scene='74/749400/Cv/1'>
 == Function ==
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 == Structural highlights ==
-SAI structure shows <scene name='74/749400/Cv/2'>two domains</scene>.  The <scene name='74/749400/Cv/3'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains ADP, aspartic acid and aminoimidazole-ribonucleotide (AIR)<ref>PMID:24598753</ref>.
+SAI structure shows <scene name='74/749400/Cv/10'>two domains</scene>. The <scene name='74/749400/Cv/11'>active site is located in a hydrophilic tunnel</scene> between the 2 domains and contains <scene name='74/749400/Cv/12'>ADP</scene>, <scene name='74/749400/Cv/13'>aspartic acid</scene> and <scene name='74/749400/Cv/14'>aminoimidazole-ribonucleotide (AIR)</scene><ref>PMID:24598753</ref>. Residues are colored according to {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}. Water molecules are shown as red spheres.
+*<scene name='74/749400/Cv/15'>Surface representation of hydrophilic tunnel</scene>.
+*<scene name='74/749400/Cv/16'>Mg coordination site</scene>.
+*<scene name='74/749400/Cv/17'>Whole active site</scene>.
 </StructureSection>
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 **[[1a48]] – ySAI - yeast<br />
-**[[3r9r]] – SAI – ''Mycobacterium abscessus'' <br />
+**[[3r9r]], [[6yvq]] – MaSAI – ''Mycobacterium abscessus'' <br />
 **[[3kre]] – SAI – ''Ehrlichia chaffeensis'' <br />
 **[[1kut]] – SAI – ''Thermotoga maritima''<br />
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 **[[2gqr]] – EcSAI + ADP – ''Escherichia coli''<br />
 **[[2gqs]] – EcSAI + ADP + AICAR <br />
+**[[6yy6]], [[6yy7]], [[6yy8]], [[6yy9]], [[6yya]], [[6yyb]], [[6yyc]], [[6yyd]], [[6z0q]], [[6z0r]] – MaSAI + inhibitor<br />
+**[[6yx3]] – MaSAI + ATP <br />
 *SAICAR synthetase type-1
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 == References ==
 <references/>
+[[Category:Topic Page]]