SAGA-associated factor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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 <StructureSection load='3mhs' size='340' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow), UB8P (grey), glycerol and Zn+2 ions (grey) (PDB entry [[3mhs]])' scene=''>
-'''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes<ref>PMID:19731963</ref>.<br />
+'''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA ('''S'''pt-'''A'''da-'''G'''cn5-'''A'''cetyl transferase) which facilitates transcription of stress-activated genes<ref>PMID:19731963</ref>.<br />
+*  '''SGF11''' is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.<br />
 *  '''SGF29''' binds methylated lysine of histone H3 and is involved in transcriptional regulation<ref>PMID:23894581</ref>.<br />
-*  '''SGF11''' is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.<br />
 *  '''SGF73''' is required for the assembly of RITS complex in yeast<ref>PMID:26443059</ref>.<br />.
 </StructureSection>
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 **[[2lo2]] – ySGF zinc finger domain – yeast – NMR<br />
 **[[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br />
-**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – yUBP8 + Sus1 +SGF73 - yeast<br />
+**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – ySGF11 + SGF73 + yUBP8 + SUS1 <br />
-**[[3mhs]] – yUBP8 + Sus1 +SGF73 + ubiquitin<br />
+**[[3mhs]], [[6aqr]] – ySGF11 + SGF73 + yUBP8 + SUS1 + ubiquitin<br />
-**[[4w4u]], [[6aqr]] – ySGF11 + SUS1+ SGF73 + ubiquitin carboxyl terminal hydrolase<br />
+**[[4w4u]], [[6aqr]] – ySGF11 + ySGF73 + SUS1 + ubiquitin carboxyl terminal hydrolase<br />
-**[[4zux]] – yUBP8 + SUS1 + SGF11 +SGF73 + ubiquitin + histone H3.2, H4, H2A, H2B + DNA<br />
+**[[4zux]] – SGF11 + SGF73 + yUBP8 + SUS1 + ubiquitin + histone H3.2, H4, H2A, H2B + DNA<br />
+**[[6tbm]] – KpSGF + TBP + SPT20 + SPT8 + transcription coactivator HFI1 + TFIID + polyubiquitin + SUS1 + transcription-associated protein – ''Komagataela phaffii'' - Cryo EM<br />
 *SGF29
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 *SGF73
+**[[6t9i]], [[6t9k]], [[6t9l]] – ySGF in transcription coactivator SAGA – Cryo EM<br />
 **[[2lo3]] – ySGF zinc finger domain – NMR<br />
+**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – ySGF73 + yUBP8 + Sus1 <br />
+**[[3mhs]] – ySGF73 + yUBP8 + Sus1 + ubiquitin<br />
+**[[6tb4]] – KpSGF + TBP + SPT20 + transcription coactivator HFI1 + TFIID + ADA3 + transcription-associated protein - Cryo EM<br />
 }}
 == References ==
 <references/>
 [[Category: Topic Page]]