SAGA-associated factor: Difference between revisions
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<StructureSection load='3mhs' size=' | <StructureSection load='3mhs' size='340' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow), UB8P (grey), glycerol and Zn+2 ions (grey) (PDB entry [[3mhs]])' scene=''> | ||
'''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA ( | '''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA ('''S'''pt-'''A'''da-'''G'''cn5-'''A'''cetyl transferase) which facilitates transcription of stress-activated genes<ref>PMID:19731963</ref>.<br /> | ||
* '''SGF11''' is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.<br /> | |||
* '''SGF29''' binds methylated lysine of histone H3 and is involved in transcriptional regulation<ref>PMID:23894581</ref>.<br /> | * '''SGF29''' binds methylated lysine of histone H3 and is involved in transcriptional regulation<ref>PMID:23894581</ref>.<br /> | ||
* '''SGF73''' is required for the assembly of RITS complex in yeast<ref>PMID:26443059</ref>.<br />. | * '''SGF73''' is required for the assembly of RITS complex in yeast<ref>PMID:26443059</ref>.<br />. | ||
</StructureSection> | </StructureSection> | ||
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**[[2lo2]] – ySGF zinc finger domain – yeast – NMR<br /> | **[[2lo2]] – ySGF zinc finger domain – yeast – NMR<br /> | ||
**[[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br /> | **[[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br /> | ||
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – yUBP8 + | **[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – ySGF11 + SGF73 + yUBP8 + SUS1 <br /> | ||
**[[ | **[[3mhs]], [[6aqr]] – ySGF11 + SGF73 + yUBP8 + SUS1 + ubiquitin<br /> | ||
**[[4w4u]], [[6aqr]] – ySGF11 + ySGF73 + SUS1 + ubiquitin carboxyl terminal hydrolase<br /> | |||
**[[4zux]] – SGF11 + SGF73 + yUBP8 + SUS1 + ubiquitin + histone H3.2, H4, H2A, H2B + DNA<br /> | |||
**[[6tbm]] – KpSGF + TBP + SPT20 + SPT8 + transcription coactivator HFI1 + TFIID + polyubiquitin + SUS1 + transcription-associated protein – ''Komagataela phaffii'' - Cryo EM<br /> | |||
*SGF29 | *SGF29 | ||
**[[3me9]], [[3mea]], [[3met]], [[3meu]], [[3mev]], [[3mew]], [[3mp1]], [[3mp6]] – hSGF tudor domain + histone H3 peptide – human<br /> | **[[3me9]], [[3mea]], [[3met]], [[3meu]], [[3mev]], [[3mew]], [[3mp1]], [[3mp6]], [[5c0m]] – hSGF tudor domain + histone H3 peptide – human<br /> | ||
**[[3lx7]], [[3mp8]] - hSGF tudor domain <br /> | **[[3lx7]], [[3mp8]] - hSGF tudor domain <br /> | ||
**[[5c0m]] - hSGF tudor domain + CABRA containing peptide <br /> | |||
*SGF73 | *SGF73 | ||
**[[6t9i]], [[6t9k]], [[6t9l]] – ySGF in transcription coactivator SAGA – Cryo EM<br /> | |||
**[[2lo3]] – ySGF zinc finger domain – NMR<br /> | **[[2lo3]] – ySGF zinc finger domain – NMR<br /> | ||
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]], [[4wa6]] – ySGF73 + yUBP8 + Sus1 <br /> | |||
**[[3mhs]] – ySGF73 + yUBP8 + Sus1 + ubiquitin<br /> | |||
**[[6tb4]] – KpSGF + TBP + SPT20 + transcription coactivator HFI1 + TFIID + ADA3 + transcription-associated protein - Cryo EM<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||