RmlC: Difference between revisions
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<StructureSection load='2ixc' size=' | <StructureSection load='2ixc' size='350' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code [[2ixc]]).' scene='59/597941/Cv/1'> | ||
== Function == | == Function == | ||
'''RmlC''' is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human<ref>PMID:10802738</ref>. | '''RmlC''' or '''dTDP-4-dehydrorhamnose 3,5-epimerase''' or '''dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase''' is an epimerase enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human<ref>PMID:10802738</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The <scene name='59/597941/Cv/4'>active site of RmlC contains the reaction product DTDP-L-rhamnose</scene><ref>PMID:17046787</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
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**[[2ixl]] – SsRmlC + dTDP rhamnose <br /> | **[[2ixl]] – SsRmlC + dTDP rhamnose <br /> | ||
**[[2ixk]] – PaRmlC + dTDP-keto rhamnose <br /> | **[[2ixk]] – PaRmlC + dTDP-keto rhamnose <br /> | ||
**[[6ndr]] – RmlC + dTDP-keto rhamnose – ''Legionella pneumophila''<br /> | |||
**[[1nyw]] – SsRmlC + dTDP glucose <br /> | **[[1nyw]] – SsRmlC + dTDP glucose <br /> | ||
**[[1nzc]] – SsRmlC + dTDP xylose <br /> | **[[1nzc]] – SsRmlC + dTDP xylose <br /> | ||