RmlC: Difference between revisions
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<StructureSection load='2ixc' size=' | <StructureSection load='2ixc' size='350' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code [[2ixc]]).' scene='59/597941/Cv/1'> | ||
== Function == | == Function == | ||
'''RmlC''' or '''dTDP-4-dehydrorhamnose 3,5-epimerase''' or '''dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase''' is an epimerase enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human<ref>PMID:10802738</ref>. | |||
== Relevance == | == Relevance == | ||
Inhibitors of RmlC can serve as potential antimicrobial drugs<ref>PMID:15103135</ref>. | |||
Inhibitors of RmlC can serve as potential antimicrobial drugs. | |||
== Structural highlights == | == Structural highlights == | ||
The <scene name='59/597941/Cv/4'>active site of RmlC contains the reaction product DTDP-L-rhamnose</scene><ref>PMID:17046787</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
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**[[2ixl]] – SsRmlC + dTDP rhamnose <br /> | **[[2ixl]] – SsRmlC + dTDP rhamnose <br /> | ||
**[[2ixk]] – PaRmlC + dTDP-keto rhamnose <br /> | **[[2ixk]] – PaRmlC + dTDP-keto rhamnose <br /> | ||
**[[6ndr]] – RmlC + dTDP-keto rhamnose – ''Legionella pneumophila''<br /> | |||
**[[1nyw]] – SsRmlC + dTDP glucose <br /> | **[[1nyw]] – SsRmlC + dTDP glucose <br /> | ||
**[[1nzc]] – SsRmlC + dTDP xylose <br /> | **[[1nzc]] – SsRmlC + dTDP xylose <br /> | ||
Latest revision as of 10:59, 6 March 2022
FunctionRmlC or dTDP-4-dehydrorhamnose 3,5-epimerase or dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase is an epimerase enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human[1]. RelevanceInhibitors of RmlC can serve as potential antimicrobial drugs[2]. Structural highlightsThe [3]. Water molecules are shown as red spheres. |
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3D structures of RmlC3D structures of RmlC
Updated on 06-March-2022
ReferencesReferences
- ↑ Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH. RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat Struct Biol. 2000 May;7(5):398-402. PMID:10802738 doi:10.1038/75178
- ↑ Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B. Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway. Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004, Apr 21. PMID:15103135 doi:10.1107/S0907444904005323
- ↑ Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH. RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol. 2007 Jan 5;365(1):146-59. Epub 2006 Sep 29. PMID:17046787 doi:http://dx.doi.org/10.1016/j.jmb.2006.09.063