2p4l: Difference between revisions

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 ==Structure and sodium channel activity of an excitatory I1-superfamily conotoxin==
-<StructureSection load='2p4l' size='340' side='right' caption='[[2p4l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2p4l' size='340' side='right'caption='[[2p4l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2p4l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conra Conra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P4L FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2p4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conra Conra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P4L FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4l OCA], [http://pdbe.org/2p4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p4l RCSB], [http://www.ebi.ac.uk/pdbsum/2p4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4l ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4l OCA], [https://pdbe.org/2p4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p4l RCSB], [https://www.ebi.ac.uk/pdbsum/2p4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4l ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>
+[[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </StructureSection>
 [[Category: Conra]]
+[[Category: Large Structures]]
 [[Category: Babon, J J]]
 [[Category: Buczek, O]]