Barnase: Difference between revisions
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<StructureSection load='1brn' size='350' side='right' scene='44/442736/Cv/2' caption='Barnase complex with tetranucleotide (PDB code [[1brn]])'> | |||
<StructureSection load='1brn' size=' | |||
== Function == | == Function == | ||
'''Barnase''' (BA, BActerial RiboNucleASE) is a bacterial ribonuclease synthesized and secreted by the bacterium ''Bacillus amyloliquefaciens''. | '''Barnase''' (BA, BActerial RiboNucleASE) is a bacterial [[ribonuclease]] synthesized and secreted by the bacterium ''Bacillus amyloliquefaciens''. <ref>PMID:8110767</ref> The inhibitor barstar (BST) binds to it very tightly and prevents it from digestion of the cell’s RNA. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
BA hydrolyzes RNA at GpN sites where the positively | BA hydrolyzes RNA at GpN sites where the <scene name='44/442736/Cv/4'>active site positively charged Lys and Arg coordinate the RNA phosphate group</scene> (Lys and Arg are in magenta). | ||
== 3D Structures of Barnase == | == 3D Structures of Barnase == | ||
[[Barnase 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 17:37, 20 February 2022
FunctionBarnase (BA, BActerial RiboNucleASE) is a bacterial ribonuclease synthesized and secreted by the bacterium Bacillus amyloliquefaciens. [1] The inhibitor barstar (BST) binds to it very tightly and prevents it from digestion of the cell’s RNA. RelevanceBA structure was used extensively for studying protein folding. Structural highlightsBA hydrolyzes RNA at GpN sites where the (Lys and Arg are in magenta). 3D Structures of Barnase
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