COVID-19 AlphaFold2 Models: Difference between revisions
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[[Image:SARS-Cov-2-genome.jpg|1000px|center|thumb|SARS-CoV-2 Protein Organization, from Gordon | [[Image:SARS-Cov-2-genome.jpg|1000px|center|thumb|SARS-CoV-2 Protein Organization, from Gordon | ||
et al. & Krogan (2020)<ref>PMID: 32353859 </ref> )]] | et al. & Krogan (2020)<ref>PMID: 32353859 </ref> )]] | ||
[[Image:VirusImage.jpg|left| | [[Image:VirusImage.jpg|left|330px|thumb|Organization of SARS-CoV-2 virus (from Holmes & Enjuanes (2003)<ref>pmid 12775826</ref>)]] | ||
==Background== | ==Background== | ||
At present, there are still a number of proteins from the SARS CoV-2 virus whose 3D structures have not yet been experimentally determined. [[AlphaFold]]2 was used to predict these structures using the MIT ColabFold server<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>, which was developed by [http://colab.research.google.com/github/sokrypton/ColabFold/blob/main/AlphaFold2.ipynb Sergey Ovchinnikov, Milot Mirdita and Martin Steinegger]. For each prediction, five 3D models were predicted, ranked from 1 to 5 (with 1 being the best). Views of these AlphaFold2 predictions can be seen on the Proteopedia pages:<br> | At present, there are still a number of proteins from the SARS CoV-2 virus whose 3D structures have not yet been experimentally determined. [[AlphaFold]]2 was used to predict these structures using the MIT ColabFold server<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>, which was developed by [http://colab.research.google.com/github/sokrypton/ColabFold/blob/main/AlphaFold2.ipynb Sergey Ovchinnikov, Milot Mirdita and Martin Steinegger]. For each prediction, five 3D models were predicted, ranked from 1 to 5 (with 1 being the best). Views of these AlphaFold2 predictions can be seen on the Proteopedia pages:<br> | ||