3cey: Difference between revisions

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-{{Seed}}
-[[Image:3cey.png|left|200px]]
-<!--
+==Crystal structure of L3MBTL2==
-The line below this paragraph, containing "STRUCTURE_3cey", creates the "Structure Box" on the page.
+<StructureSection load='3cey' size='340' side='right'caption='[[3cey]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3cey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CEY FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cey OCA], [https://pdbe.org/3cey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cey RCSB], [https://www.ebi.ac.uk/pdbsum/3cey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cey ProSAT]</span></td></tr>
-{{STRUCTURE_3cey|  PDB=3cey  |  SCENE=  }}
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/3cey_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cey ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The MBT repeat has been recently identified as a key domain capable of methyl-lysine histone recognition. Functional work has pointed to a role for MBT domain-containing proteins in transcriptional repression of developmental control genes such as Hox genes. In this study, L3MBTL2, a human homolog of Drosophila Sfmbt critical for Hox gene silencing, is demonstrated to preferentially recognize lower methylation states of several histone-derived peptides through its fourth MBT repeat. High-resolution crystallographic analysis of the four MBT repeats of this protein reveals its unique asymmetric rhomboid architecture, as well as binding mechanism, which preclude the interaction of the first three MBT repeats with methylated peptides. Structural elucidation of an L3MBTL2-H4K20me1 complex and comparison with other MBT-histone peptide complexes also suggests that an absence of distinct surface contours surrounding the methyl-lysine-binding pocket may underlie the lack of sequence specificity observed for members of this protein family.
-===Crystal structure of L3MBTL2===
+Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.,Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J Nucleic Acids Res. 2009 Apr;37(7):2204-10. Epub 2009 Feb 20. PMID:19233876<ref>PMID:19233876</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_19233876}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3cey" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 19233876 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_19233876}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Human]]
-CEY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEY OCA].
+[[Category: Large Structures]]
+[[Category: Allali-Hassani, A]]
-==Reference==
+[[Category: Arrowsmith, C H]]
-<ref group="xtra">PMID:19233876</ref><references group="xtra"/>
+[[Category: Bochkarev, A]]
-[[Category: Homo sapiens]]
+[[Category: Bountra, C]]
-[[Category: Allali-Hassani, A.]]
+[[Category: Crombet, L]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Dong, A]]
-[[Category: Bochkarev, A.]]
+[[Category: Edwards, A M]]
-[[Category: Bountra, C.]]
+[[Category: Guo, Y]]
-[[Category: Crombet, L.]]
+[[Category: Kozieradzki, I]]
-[[Category: Dong, A.]]
+[[Category: Loppnau, P]]
-[[Category: Edwards, A M.]]
+[[Category: Mackenzie, F]]
-[[Category: Guo, Y.]]
+[[Category: Min, J]]
-[[Category: Kozieradzki, I.]]
+[[Category: Nady, N]]
-[[Category: Loppnau, P.]]
+[[Category: Pan, P]]
-[[Category: Mackenzie, F.]]
+[[Category: Qi, C]]
-[[Category: Min, J.]]
+[[Category: Read, R]]
-[[Category: Nady, N.]]
+[[Category: Structural genomic]]
-[[Category: Pan, P.]]
+[[Category: Vedadi, M]]
-[[Category: Qi, C.]]
+[[Category: Weigelt, J]]
-[[Category: Read, R.]]
+[[Category: Zhu, H]]
-[[Category: SGC, Structural Genomics Consortium.]]
-[[Category: Vedadi, M.]]
-[[Category: Weigelt, J.]]
-[[Category: Zhu, H.]]
-[[Category: Alternative splicing]]
 [[Category: Chromatin regulator]]
 [[Category: Mbt]]
 [[Category: Metal-binding]]
 [[Category: Nucleus]]
-[[Category: Polymorphism]]
 [[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
 [[Category: Transcription]]
 [[Category: Transcription regulation]]
 [[Category: Transcription regulator]]
-[[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  5 09:01:18 2009''