3cey: Difference between revisions
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==Crystal structure of L3MBTL2== | ==Crystal structure of L3MBTL2== | ||
<StructureSection load='3cey' size='340' side='right' caption='[[3cey]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3cey' size='340' side='right'caption='[[3cey]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3cey]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3cey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CEY FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL2 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L3MBTL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cey OCA], [https://pdbe.org/3cey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cey RCSB], [https://www.ebi.ac.uk/pdbsum/3cey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cey ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Allali-Hassani, A]] | [[Category: Allali-Hassani, A]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] |