Estrogens: Difference between revisions
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'''Estrogens, their receptors and relevant proteins.''' | '''Estrogens, their receptors and relevant proteins.''' | ||
There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy. | There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. <scene name='89/895670/Cv/1'>Estradiol</scene> is an important estrogen steroid hormone in both women and men. It is a typical steroid with core four-ring system (ABCD), composed of 17 carbon atoms. Another estrogen called estetrol (E4) is produced only during pregnancy. | ||
*[[Estrogen receptor]] | *[[Estrogen receptor]] | ||
<scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | <scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | ||
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*[[ATPase family AAA domain-containing protein 2]] | *[[ATPase family AAA domain-containing protein 2]] | ||
*[[Hypoxia-Inducible Factors]] | *[[Hypoxia-Inducible Factors]] | ||
'''Estriol''' | |||
*[[Cytochrome P450 3D structures]]: [[1x8v]] - MtP450 CYP51 (mutant)+estriol<br /> | |||
'''Estetrol''' | |||
*[[3l03]] - Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol) | |||
</StructureSection> | </StructureSection> | ||
See also: | See also: | ||
*[[Estrogen receptor]] | |||
*[[Nuclear receptors]] | *[[Nuclear receptors]] | ||
*[[Steroid Hormones and their receptors]] | |||
== References == | == References == | ||
<references/> | <references/> | ||