2jf4: Difference between revisions

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[[Image:2jf4.jpg|left|200px]]


{{Structure
==Family 37 trehalase from Escherichia coli in complex with validoxylamine==
|PDB= 2jf4 |SIZE=350|CAPTION= <scene name='initialview01'>2jf4</scene>, resolution 2.20&Aring;
<StructureSection load='2jf4' size='340' side='right'caption='[[2jf4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE= <scene name='pdbsite=ACD:Vdm+Binding+Site+For+Chain+A'>ACD</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=VDM:(1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL'>VDM</scene>
<table><tr><td colspan='2'>[[2jf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JF4 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha,alpha-trehalase Alpha,alpha-trehalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.28 3.2.1.28] </span>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VDM:(1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL'>VDM</scene></td></tr>
|GENE=  
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha,alpha-trehalase Alpha,alpha-trehalase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.28 3.2.1.28] </span></td></tr>
|RELATEDENTRY=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jf4 OCA], [https://pdbe.org/2jf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2jf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jf4 ProSAT]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jf4 OCA], [http://www.ebi.ac.uk/pdbsum/2jf4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jf4 RCSB]</span>
</table>
}}
== Function ==
 
[[https://www.uniprot.org/uniprot/TREA_ECOLI TREA_ECOLI]] Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.[HAMAP-Rule:MF_01060]
'''FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH VALIDOXYLAMINE'''
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2JF4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JF4 OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jf4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jf4 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Alpha,alpha-trehalase]]
[[Category: Alpha,alpha-trehalase]]
[[Category: Escherichia coli]]
[[Category: Ecoli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Chiara, J L.]]
[[Category: Chiara, J L]]
[[Category: Davies, G J.]]
[[Category: Davies, G J]]
[[Category: Garcia, A.]]
[[Category: Garcia, A]]
[[Category: Gibson, R P.]]
[[Category: Gibson, R P]]
[[Category: Gloster, T M.]]
[[Category: Gloster, T M]]
[[Category: Gracia, I Storch De.]]
[[Category: Gracia, I Storch De]]
[[Category: Roberts, S.]]
[[Category: Roberts, S]]
[[Category: Warren, R A.J.]]
[[Category: Warren, R A.J]]
[[Category: family 37]]
[[Category: Family 37]]
[[Category: glycosidase]]
[[Category: Glycosidase]]
[[Category: glycoside hydrolase]]
[[Category: Glycoside hydrolase]]
[[Category: hydrolase]]
[[Category: Hydrolase]]
[[Category: inhibitor]]
[[Category: Inhibitor]]
[[Category: periplasmic]]
[[Category: Periplasmic]]
[[Category: trehalase]]
[[Category: Trehalase]]
[[Category: validoxylamine]]
[[Category: Validoxylamine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:19 2008''

Latest revision as of 11:09, 19 January 2022

Family 37 trehalase from Escherichia coli in complex with validoxylamineFamily 37 trehalase from Escherichia coli in complex with validoxylamine

Structural highlights

2jf4 is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Activity:Alpha,alpha-trehalase, with EC number 3.2.1.28
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TREA_ECOLI] Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.[HAMAP-Rule:MF_01060]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2jf4, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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