2jax: Difference between revisions

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[[Image:2jax.jpg|left|200px]]


{{Structure
==Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis==
|PDB= 2jax |SIZE=350|CAPTION= <scene name='initialview01'>2jax</scene>, resolution 3.22&Aring;
<StructureSection load='2jax' size='340' side='right'caption='[[2jax]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Atp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Atp+Binding+Site+For+Chain+A'>AC2</scene> and <scene name='pdbsite=AC3:Unk+Binding+Site+For+Chain+A'>AC3</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
<table><tr><td colspan='2'>[[2jax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAX FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
|GENE=  
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jax OCA], [https://pdbe.org/2jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jax RCSB], [https://www.ebi.ac.uk/pdbsum/2jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jax ProSAT]</span></td></tr>
 
</table>
'''UNIVERSAL STRESS PROTEIN RV2623 FROM MYCOBATERIUM TUBERCULOSIS'''
== Function ==
 
[[https://www.uniprot.org/uniprot/Y2623_MYCTU Y2623_MYCTU]] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2JAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA].  
Check<jmol>
[[Category: Mycobacterium tuberculosis]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jax_consurf.spt"</scriptWhenChecked>
[[Category: Bartunik, H D.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Bourenkov, G.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Oberschall, A.]]
  </jmolCheckbox>
[[Category: Strizhov, N.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jax ConSurf].
[[Category: ATP]]
<div style="clear:both"></div>
[[Category: UNX]]
__TOC__
[[Category: atp binding]]
</StructureSection>
[[Category: protein binding]]
[[Category: Large Structures]]
[[Category: universal stress protein]]
[[Category: Myctu]]
[[Category: usp]]
[[Category: Bartunik, H D]]
 
[[Category: Bourenkov, G]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:25:21 2008''
[[Category: Oberschall, A]]
[[Category: Strizhov, N]]
[[Category: Atp binding]]
[[Category: Protein binding]]
[[Category: Universal stress protein]]
[[Category: Usp]]

Latest revision as of 11:05, 19 January 2022

Universal Stress Protein Rv2623 from Mycobaterium TuberculosisUniversal Stress Protein Rv2623 from Mycobaterium Tuberculosis

Structural highlights

2jax is a 1 chain structure with sequence from Myctu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[Y2623_MYCTU] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2jax, resolution 3.22Å

Drag the structure with the mouse to rotate

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