Plectin: Difference between revisions

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Jae-Geun Song, Michal Harel, Alexander Berchansky

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-<Structure load='1sh6' size='400'  caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '><!--
+<Structure load='1sh6' size='400'  caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '>
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+== Function ==
-Or use the four-green-boxes-button to insert scrollable text adjacent
+'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms.
-to a Jmol applet. Check out the other buttons as well!
--->
+For more details see [[Group:MUZIC:Plectin]].
-'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). For more details see [[Group:MUZIC:Plectin]].
+==Disease ==
+Mutations in plectin result in skin fragility and blister formation<ref>PMID:15810881</ref>.
 ==3D structures of plectin==
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 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1mb8]] – hPCN actin-binding domain – human<br />
+[[1mb8]], [[4q59]] – hPCN actin-binding domain 59-293 – human<br />
+[[3pe0]] - hPCN plakin domain residues 747-918<br />
+[[2odu]], [[2odv]] – hPCN plakin domain residues 300-530 (mutant)<br />
+[[3pdy]] – hPCN plakin domain repeats 3-4 653-848<br />
+[[5j1g]] – hPCN plakin domain repeats 7-8 1004-1233<br />
+[[5j1f]], [[5j1h]] – hPCN plakin domain repeats 5-6 750-818, 889-1006<br />
+[[5j1i]] – hPCN plakin domain repeats 7-9 1104-1372<br />
+[[4gdo]] – hPCN rod domain 1382-1420<br />
+[[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<br />
+[[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br />
+[[2n03]] – hPCN C-terminal repeat domain 6 4403-4606 - NMR<br />
 [[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br />
-[[3pdy]], [[3pe0]] - hPCN plakin domain<br />
-[[2odu]], [[2odv]] – hPCN plakin domain (mutant)<br />
-[[4gdo]] – hPCN rod domain<br />
-[[3f7p]] - hPCN actin-binding domain + integrin β4 residues 1126-1370
+== References ==
 <references/>
 [[Category:Topic Page]]