2zy2: Difference between revisions
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==dodecameric L-aspartate beta-decarboxylase== | ==dodecameric L-aspartate beta-decarboxylase== | ||
<StructureSection load='2zy2' size='340' side='right' caption='[[2zy2]], [[Resolution|resolution]] 3.30Å' scene=''> | <StructureSection load='2zy2' size='340' side='right'caption='[[2zy2]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zy2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2zy2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._atcc_19121 Pseudomonas sp. atcc 19121]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZY2 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zy3|2zy3]], [[2zy4|2zy4]], [[2zy5|2zy5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zy3|2zy3]], [[2zy4|2zy4]], [[2zy5|2zy5]]</div></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">asdP ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">asdP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=206121 Pseudomonas sp. ATCC 19121])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aspartate_4-decarboxylase Aspartate 4-decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.12 4.1.1.12] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zy2 OCA], [https://pdbe.org/2zy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zy2 RCSB], [https://www.ebi.ac.uk/pdbsum/2zy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zy2 ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/ASDP_PSESP ASDP_PSESP]] Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity. Has high activity with L-aspartate, and much lower activity with D-aspartate, L-lysine and L-glutamine.<ref>PMID:16847601</ref> <ref>PMID:19368885</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/2zy2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/2zy2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zy2 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2zy2" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Aspartate decarboxylase 3D structures|Aspartate decarboxylase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Aspartate 4-decarboxylase]] | [[Category: Aspartate 4-decarboxylase]] | ||
[[Category: Pseudomonas sp.]] | [[Category: Large Structures]] | ||
[[Category: Chen, H J | [[Category: Pseudomonas sp. atcc 19121]] | ||
[[Category: Ko, T P | [[Category: Chen, H J]] | ||
[[Category: Lee, C Y | [[Category: Ko, T P]] | ||
[[Category: Wang, A H.J | [[Category: Lee, C Y]] | ||
[[Category: Wang, N C | [[Category: Wang, A H.J]] | ||
[[Category: Wang, N C]] | |||
[[Category: Aminotransferase]] | [[Category: Aminotransferase]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Pyridoxal 5'-phosphate]] | [[Category: Pyridoxal 5'-phosphate]] | ||