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[[Image:2ef7.png|left|200px]]


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==Crystal structure of ST2348, a hypothetical protein with CBS domains from Sulfolobus tokodaii strain7==
The line below this paragraph, containing "STRUCTURE_2ef7", creates the "Structure Box" on the page.
<StructureSection load='2ef7' size='340' side='right'caption='[[2ef7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ef7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EF7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ef7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ef7 OCA], [https://pdbe.org/2ef7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ef7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ef7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ef7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ef7 TOPSAN]</span></td></tr>
{{STRUCTURE_2ef7|  PDB=2ef7  |  SCENE=  }}
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2ef7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ef7 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a hypothetical protein ST2348 (GI: 47118305) from the hyperthermophilic bacteria Sulfolobus tokodaii has been determined using X-ray crystallography. The protein consists of two CBS (cystathione beta synthase) domains, whose function has been analyzed and reported here. PSI-BLAST shows a conservation of this domain in about 100 proteins in various species. However, none of the close homologs of ST2348 have been functionally characterized so far. Structure and sequence comparison of ST2348 with human AMP-kinase gamma1 subunit and the CBS domain pair of bacterial IMP dehydrogenase is suggestive of its binding to AMP and ATP. A highly conserved residue Asp118, located in a negatively charged patch near the ligand binding cleft, could serve as a site for phosphorylation similar to that found in the chemotatic signal protein CheY and thereby ST2348 can function as a signal transduction molecule.


===Crystal structure of ST2348, a hypothetical protein with CBS domains from Sulfolobus tokodaii strain7===
Crystal structure of ST2348, a CBS domain protein, from hyperthermophilic archaeon Sulfolobus tokodaii.,Ragunathan P, Kumarevel T, Agari Y, Shinkai A, Kuramitsu S, Yokoyama S, Ponnuraj K Biochem Biophys Res Commun. 2008 Oct 10;375(1):124-8. Epub 2008 Aug 6. PMID:18691556<ref>PMID:18691556</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18691556}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2ef7" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18691556 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18691556}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2EF7 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EF7 OCA].
[[Category: Sulto]]
 
[[Category: Agari, Y]]
==Reference==
[[Category: Karthe, P]]
<ref group="xtra">PMID:18691556</ref><references group="xtra"/>
[[Category: Kumarevel, T]]
[[Category: Sulfolobus tokodaii]]
[[Category: Kuramitsu, S]]
[[Category: Agari, Y.]]
[[Category: Structural genomic]]
[[Category: Karthe, P.]]
[[Category: Yokoyama, S]]
[[Category: Kumarevel, T.]]
[[Category: Kuramitsu, S.]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama, S.]]
[[Category: Cbs-domain]]
[[Category: Cbs-domain]]
[[Category: National project on protein structural and functional analyse]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nppsfa]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:01:44 2010''

Latest revision as of 20:23, 15 December 2021

Crystal structure of ST2348, a hypothetical protein with CBS domains from Sulfolobus tokodaii strain7Crystal structure of ST2348, a hypothetical protein with CBS domains from Sulfolobus tokodaii strain7

Structural highlights

2ef7 is a 2 chain structure with sequence from Sulto. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of a hypothetical protein ST2348 (GI: 47118305) from the hyperthermophilic bacteria Sulfolobus tokodaii has been determined using X-ray crystallography. The protein consists of two CBS (cystathione beta synthase) domains, whose function has been analyzed and reported here. PSI-BLAST shows a conservation of this domain in about 100 proteins in various species. However, none of the close homologs of ST2348 have been functionally characterized so far. Structure and sequence comparison of ST2348 with human AMP-kinase gamma1 subunit and the CBS domain pair of bacterial IMP dehydrogenase is suggestive of its binding to AMP and ATP. A highly conserved residue Asp118, located in a negatively charged patch near the ligand binding cleft, could serve as a site for phosphorylation similar to that found in the chemotatic signal protein CheY and thereby ST2348 can function as a signal transduction molecule.

Crystal structure of ST2348, a CBS domain protein, from hyperthermophilic archaeon Sulfolobus tokodaii.,Ragunathan P, Kumarevel T, Agari Y, Shinkai A, Kuramitsu S, Yokoyama S, Ponnuraj K Biochem Biophys Res Commun. 2008 Oct 10;375(1):124-8. Epub 2008 Aug 6. PMID:18691556[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Ragunathan P, Kumarevel T, Agari Y, Shinkai A, Kuramitsu S, Yokoyama S, Ponnuraj K. Crystal structure of ST2348, a CBS domain protein, from hyperthermophilic archaeon Sulfolobus tokodaii. Biochem Biophys Res Commun. 2008 Oct 10;375(1):124-8. Epub 2008 Aug 6. PMID:18691556 doi:10.1016/j.bbrc.2008.07.140

2ef7, resolution 2.10Å

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