2yu7: Difference between revisions

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-[[Image:2yu7.png|left|200px]]
-{{STRUCTURE_2yu7|  PDB=2yu7  |  SCENE=  }}
+==Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A==
+<StructureSection load='2yu7' size='340' side='right'caption='[[2yu7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-===Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2yu7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YU7 FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-==About this Structure==
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[2yu7]] is a 2 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YU7 OCA].
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yu7 OCA], [https://pdbe.org/2yu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yu7 RCSB], [https://www.ebi.ac.uk/pdbsum/2yu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yu7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yu7 TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN]] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>  [[https://www.uniprot.org/uniprot/NKG2A_HUMAN NKG2A_HUMAN]] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yu/2yu7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yu7 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-[[Category: Homo sapiens]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Protein-tyrosine-phosphatase]]
-[[Category: Inoue, M.]]
+[[Category: Inoue, M]]
-[[Category: Kasai, T.]]
+[[Category: Kasai, T]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa, T]]
-[[Category: Koshiba, S.]]
+[[Category: Koshiba, S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Structural genomic]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama, S]]
 [[Category: National project on protein structural and functional analyse]]
 [[Category: Nppsfa]]
@@ Line 24: / Line 42: @@
 [[Category: Phosphotyrosine binding domain]]
 [[Category: Protein-peptide complex]]
-[[Category: Riken structural genomics/proteomics initiative]]
 [[Category: Rsgi]]
 [[Category: Sh2 domain]]
 [[Category: Signal transduction]]
 [[Category: Signaling protein]]
-[[Category: Structural genomic]]